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jmc
April 12th 08, 05:25 AM
Meep's finally off the Clomicalm and on amytriptyline. Probably because
the vet got it from a compounding pharmacy, there was no drug insert for
it. Her dose is 2.5mg, once per day. Capsules.

I see it's an antihistamine, as well as having analgesic affects. I see
it's used for human interstitial cystitis as well.

However, Meep's showing a couple of possible side effects I don't seem
to see for humans:

Increased appetite (not necessarily a bad thing, she's a bit thin)
Increased activity
Increased vocalization

She hasn't been this active, or this talkative, in a long time. Also,
she's only been on the ami for two days - is that long enough to have
this effect? Or is this just because she's off the clomicalm?

What are the normal possible side effects of amitriptyline in cats?

jmc

Phil P.
April 12th 08, 10:21 AM
"jmc" > wrote in message
...
> Meep's finally off the Clomicalm and on amytriptyline. Probably because
> the vet got it from a compounding pharmacy, there was no drug insert for
> it. Her dose is 2.5mg, once per day. Capsules.
>
> I see it's an antihistamine, as well as having analgesic affects. I see
> it's used for human interstitial cystitis as well.

Actually, its a tricyclic anti-depressant


>
> However, Meep's showing a couple of possible side effects I don't seem
> to see for humans:
>
> Increased appetite (not necessarily a bad thing, she's a bit thin)
> Increased activity
> Increased vocalization

Those are fairly common side effects of the drug in cats- but they should
be very mild with such a low dose. I'm thinking the strength might be a
little high. The problem with compounded drugs is you never know if your
getting the correct formulation and the right strength. This really become
obvious in the refills when you notice changes in efficacy and behavior from
refill to refill. If you're forced to buy compounded drugs, its best to by
a 6 or 12 month supply that's compounded from the same lot. This way its a
lot easier to make dosage adjustments. Otherwise, you have to practically
start from scratch with each refill because they might not be the same as
the previous one. The right dose should produce a barely perceptible calming
effect.

Is there any way you can get Merck's amytriptyline even if you have to pay a
little more?

>
> She hasn't been this active, or this talkative, in a long time. Also,
> she's only been on the ami for two days - is that long enough to have
> this effect? Or is this just because she's off the clomicalm?
>
> What are the normal possible side effects of amitriptyline in cats?

Appetite can go either way- increase or decrease. Water consumption might
increase. There could be heart-related issues- rhythm disturbances- but I
doubt it at such a low dose. Still you might want to have your vet run an
EKG to be on the safe side.

I think the constant moving around from place to place and having to adapt
to new environments every few months might be exacerbating her FIC.

Phil

jmc
April 12th 08, 01:31 PM
Suddenly, without warning, Phil P. exclaimed (4/12/2008 6:51 PM):
> "jmc" > wrote in message
> ...
>> Meep's finally off the Clomicalm and on amytriptyline. Probably because
>> the vet got it from a compounding pharmacy, there was no drug insert for
>> it. Her dose is 2.5mg, once per day. Capsules.
>>
>> I see it's an antihistamine, as well as having analgesic affects. I see
>> it's used for human interstitial cystitis as well.
>
> Actually, its a tricyclic anti-depressant
>
Sorry, I meant to say *also* an antihistamine (actually, what it said
was, "has strong antihistamine effects" or something similar).
>
>> However, Meep's showing a couple of possible side effects I don't seem
>> to see for humans:
>>
>> Increased appetite (not necessarily a bad thing, she's a bit thin)
>> Increased activity
>> Increased vocalization
>
> Those are fairly common side effects of the drug in cats- but they should
> be very mild with such a low dose. I'm thinking the strength might be a
> little high. The problem with compounded drugs is you never know if your
> getting the correct formulation and the right strength. This really become
> obvious in the refills when you notice changes in efficacy and behavior from
> refill to refill. If you're forced to buy compounded drugs, its best to by
> a 6 or 12 month supply that's compounded from the same lot. This way its a
> lot easier to make dosage adjustments. Otherwise, you have to practically
> start from scratch with each refill because they might not be the same as
> the previous one. The right dose should produce a barely perceptible calming
> effect.
>
> Is there any way you can get Merck's amytriptyline even if you have to pay a
> little more?
>

Not from here. But we'll be back in the US in June, I'll get a proper
prescription then.

>> She hasn't been this active, or this talkative, in a long time. Also,
>> she's only been on the ami for two days - is that long enough to have
>> this effect? Or is this just because she's off the clomicalm?
>>
>> What are the normal possible side effects of amitriptyline in cats?
>
> Appetite can go either way- increase or decrease. Water consumption might
> increase. There could be heart-related issues- rhythm disturbances- but I
> doubt it at such a low dose. Still you might want to have your vet run an
> EKG to be on the safe side.
>
> I think the constant moving around from place to place and having to adapt
> to new environments every few months might be exacerbating her FIC.
>
> Phil

I'll have to keep an eye on the heart issues, she has a grade 3 heart
murmur (sometimes it's intermittent).

Thanks for the info.

jmc