more about interferon side effects

On Jun 10, 2:32*am, "Phil P." wrote:
"calvin" wrote:
On Jun 9, 12:11 pm, "Phil P." wrote:
I didn't stubbornly cling to anything. *I just wanted to be
sure
You should have been sure after I posted excerpts on the safety of IFN from
the 2 top veterinary drug handbooks in your first thread.
Yet you can't resist adding more insults.

I know. I tried really hard to resist- but its just too hard to resist
insulting someone as obtuse as you. I'm sure you're used to it.

It was an act of non-obtuseness to declare that
I accept everything that you have said. One would have
thought the insults would have stopped at that point.

It appears that you have some hostility issues.

Yeah, I know. I've got to try to be more tolerant of obtuse and obstinate
people no matter how aggravating they are. Its on my "to do" list.

If it is so harmless, why is it given only during alternate
seven-day periods?

7 on/7 off has nothing to do with safety. This form of interferon is derived
from human leukocytes, its theroretically possible that cats may develop
anti-IFN antibodies that could inactivate the IFN. However, this has only
occurred in some cats receiving high doses (50,000 IU) SC, IM, or IP.
Anti-IFN antibody production as *never* been documented in cats receiving
low, oral doses-- even cats receiving IFN orally continiously.

Since this cat eats like a hog, I can be sure that if I put
the interferon on the top of his food he will get it all. *He
always cleans his first plate. *Is it ok to give the interferon
this way, or should I be squirting it into his mouth directly?

Yes- administer the IFN directly into his mouth. *Do not* mix it in the
food. *Once again, "Oral interferon works by binding to mucosal receptors in
the oropharynx where it triggers the release of cytokines. *The cytokines,
not the interferon, circulate through the system and stimulate the cat's
immune system." If you mix the IFN in the food, it will be digested with the
food and destroyed. The dose is so low, that the IFN must come in direct
contact with the mucosal surfaces in the oropharynx in order to be absorbed.

Thank you. You said that as if I was just automatically
supposed to have known what "Oral interferon works by binding
to mucosal receptors in the oropharynx where it triggers
the release of cytokines" meant.

This means that none of the interferon given so far has had
any effect, and I'm starting over today from square one.
Better to know the truth now than never, though, and one
more insult might have kept me from ever asking the
question (eg. I'll never ask 'Matthew' a question).

"calvin" wrote in message
...
On Jun 10, 2:32 am, "Phil P." wrote:
"calvin" wrote:
On Jun 9, 12:11 pm, "Phil P." wrote:
I didn't stubbornly cling to anything. I just wanted to be
sure
You should have been sure after I posted excerpts on the safety of IFN
from
the 2 top veterinary drug handbooks in your first thread.
Yet you can't resist adding more insults.

I know. I tried really hard to resist- but its just too hard to resist
insulting someone as obtuse as you. I'm sure you're used to it.

It was an act of non-obtuseness to declare that
I accept everything that you have said. One would have
thought the insults would have stopped at that point.

It appears that you have some hostility issues.

Yeah, I know. I've got to try to be more tolerant of obtuse and obstinate
people no matter how aggravating they are. Its on my "to do" list.

If it is so harmless, why is it given only during alternate
seven-day periods?

7 on/7 off has nothing to do with safety. This form of interferon is
derived
from human leukocytes, its theroretically possible that cats may develop
anti-IFN antibodies that could inactivate the IFN. However, this has only
occurred in some cats receiving high doses (50,000 IU) SC, IM, or IP.
Anti-IFN antibody production as *never* been documented in cats receiving
low, oral doses-- even cats receiving IFN orally continiously.

Since this cat eats like a hog, I can be sure that if I put
the interferon on the top of his food he will get it all. He
always cleans his first plate. Is it ok to give the interferon
this way, or should I be squirting it into his mouth directly?

Yes- administer the IFN directly into his mouth. *Do not* mix it in the
food. Once again, "Oral interferon works by binding to mucosal receptors
in
the oropharynx where it triggers the release of cytokines. The cytokines,
not the interferon, circulate through the system and stimulate the cat's
immune system." If you mix the IFN in the food, it will be digested with
the
food and destroyed. The dose is so low, that the IFN must come in direct
contact with the mucosal surfaces in the oropharynx in order to be
absorbed.

Thank you. You said that as if I was just automatically
supposed to have known what "Oral interferon works by binding
to mucosal receptors in the oropharynx where it triggers
the release of cytokines" meant.

This means that none of the interferon given so far has had
any effect, and I'm starting over today from square one.
Better to know the truth now than never, though, and one
more insult might have kept me from ever asking the
question (eg. I'll never ask 'Matthew' a question).


Why just because I and others need to break out the etch a sketch and the
crayons for you.

THANK YOU My head starts to hurt everytime I see your display name.

I knew you could not resist to say something

calvin wrote:
On Jun 9, 6:14 pm, "Matthew" wrote:
"calvin" wrote:
So far I've spent $241 on vet bills for this stray tomcat.
Expensive trolling, wouldn't you say?

When you spend over $10,000 than you can comment
about expensive. That was the cost to save my Rumble
and worth every freaking cent.

You don't seem able to grasp the point of anything I say.
I wasn't talking about lifetime vet bills and other cat
expenses. I doubt if you would want to get into that,
or maybe you would because you might think other
people would be impressed by you.

I was talking about money spent during the past three
weeks on a stray tomcat, which would make for
expensive trolling.

Have a nice life. I'm not going to respond to anything
else that you write (or 'cybercat' either, or MLB).


Thank Heaven for small favors! MLB

"Matthew" wrote
I knew you could not resist to say something

psssst ... ocd

"cybercat" wrote in message
...

"Matthew" wrote
I knew you could not resist to say something

psssst ... ocd


Pssst Fracked in the head ;-)

"calvin" wrote in message
...
On Jun 10, 2:32 am, "Phil P." wrote:

Since this cat eats like a hog, I can be sure that if I put
the interferon on the top of his food he will get it all. He
always cleans his first plate. Is it ok to give the interferon
this way, or should I be squirting it into his mouth directly?

Yes- administer the IFN directly into his mouth. *Do not* mix it in the
food. Once again, "Oral interferon works by binding to mucosal receptors
in
the oropharynx where it triggers the release of cytokines. The cytokines,
not the interferon, circulate through the system and stimulate the cat's
immune system." If you mix the IFN in the food, it will be digested with
the
food and destroyed. The dose is so low, that the IFN must come in direct
contact with the mucosal surfaces in the oropharynx in order to be
absorbed.

Thank you. You said that as if I was just automatically
supposed to have known what "Oral interferon works by binding
to mucosal receptors in the oropharynx where it triggers
the release of cytokines" meant.


Silly me- I assumed you had a basic understanding of simple high school
biology. OK, I'll try to explain this in terms you should understand: The
outer dry surface of the body is called "skin". The moist surfaces of the
mouth and throat are called mucus membrane or "mucosa" because it secretes
mucus. The receptors to which interferon binds are located in the mucosa at
the back of the mouth and beginning of the throat. Are you still with me?
Mixing interferon in food would have the same effect as gargling with
mouthwash while there's food in your mouth. With food in your mouth, very
little mouthwash would reach the mucus membrane of your mouth where the
germs are. You want the interferon to come in direct contact with the
mucosal surfaces in the mouth and throat. OK?

On Jun 11, 9:12*am, "Phil P." wrote:
"calvin" wrote:
Thank you. *You said that as if I was just automatically
supposed to have known what "Oral interferon works by binding
to mucosal receptors in the oropharynx where it triggers
the release of cytokines" meant.

Silly me- I assumed you had a basic understanding of simple high school
biology. *OK, I'll try to explain this in terms you should understand: The
outer dry surface of the body is called "skin". *The moist surfaces of the
mouth and throat are called mucus membrane or "mucosa" because it secretes
mucus. The receptors to which interferon binds are located in the mucosa at
the back of the mouth and beginning of the throat. *Are you still with me?
Mixing interferon in food would have the same effect as gargling with
mouthwash while there's food in your mouth. With food in your mouth, very
little mouthwash would reach the mucus membrane of your mouth where the
germs are. You want the interferon to come in direct contact with the
mucosal surfaces in the mouth and throat. *OK?

Okay, and I will ask no more questions. Obviously you know
very much about cats, but it would be better to find answers
from someone who is not so hostile and insulting, and from some
place other than this forum, which has declined into negativity
during the past few years since I was last productively involved
with it. Best wishes to you all, though.

"calvin" wrote in message
...
On Jun 11, 9:12 am, "Phil P." wrote:
"calvin" wrote:
Thank you. You said that as if I was just automatically
supposed to have known what "Oral interferon works by binding
to mucosal receptors in the oropharynx where it triggers
the release of cytokines" meant.

Silly me- I assumed you had a basic understanding of simple high school
biology. OK, I'll try to explain this in terms you should understand: The
outer dry surface of the body is called "skin". The moist surfaces of the
mouth and throat are called mucus membrane or "mucosa" because it secretes
mucus. The receptors to which interferon binds are located in the mucosa
at
the back of the mouth and beginning of the throat. Are you still with me?
Mixing interferon in food would have the same effect as gargling with
mouthwash while there's food in your mouth. With food in your mouth, very
little mouthwash would reach the mucus membrane of your mouth where the
germs are. You want the interferon to come in direct contact with the
mucosal surfaces in the mouth and throat. OK?

Okay, and I will ask no more questions. Obviously you know
very much about cats, but it would be better to find answers
from someone who is not so hostile and insulting, and from some
place other than this forum, which has declined into negativity
during the past few years since I was last productively involved
with it. Best wishes to you all, though.



Hope your cats pulls through.and the person you talk to has plenty of
aspirin plus crayons

And you posted 1 time in October of 2007 and 6 times in June of 2008 talking
about your cat dying suddenly. You have never been productive in this
group. If you had been Phil would have known how to deal with you

On Jun 11, 11:01*am, "Matthew"
wrote:
And you posted 1 time in October of 2007 and 6 times in June of 2008 talking
about your cat dying suddenly. *You have never been productive in this
group. *If you had been Phil would have known how to deal with you.

2005 2006

"calvin" wrote in message
...
On Jun 11, 11:01 am, "Matthew"
wrote:
And you posted 1 time in October of 2007 and 6 times in June of 2008
talking
about your cat dying suddenly. You have never been productive in this
group. If you had been Phil would have known how to deal with you.

2005 2006

I was here under a different addy also than. Phil would have definitely
know how to deal with you if it was that long ago. SO would I