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more about interferon side effects



 
 
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  #31  
Old June 7th 09, 06:19 PM posted to rec.pets.cats.health+behav
Calvin
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Posts: 86
Default more about interferon side effects

On Jun 7, 12:50*pm, "Phil P." wrote:
"calvin" wrote:

Mr. P, I wasn't asking why the cat was prescribed never
ending medication, I was expressing concern that any
harm that might come from it would build up indefinitely.


First of all, the oral 30 IU dose is not much more than a cat with an normal
immune system would produce. Second, there is no build-up because the
interferon you're giving your cat is completely destroyed by gastric acid in
the stomach. So there is no liver damage or any other kind of damage. Oral
interferon works by binding to mucosal receptors in the oropharynx where it
triggers the release of cytokines. *The cytokines, not the interferon,
circulate through the system and stimulate the cat's immune system. Do you
understand that?

You're smart, no doubt, but you don't seem to be able any
better than anyone else to grasp the point I'm trying to make
about that.


I fully understand the point you're trying to make. Your point just has no
merit and its just not based on facts or any evidence.

Take liver damage, for example. *I won't be able
to see that it is happening, nor will the vet. *So the damage goes
on and on, if there is liver damage. *That's just an example.


You're not grasping the *fact* that for the last 12-15 years thousands of
FeLV+ cats have been given oral interferon for years- usually *the rest of
their*lives*- and *no* adverse effects of *any kind* have *ever* been
reported.

1) "When used orally in cats, adverse effects have apparently not yet been
noted." (Plumb's Veterinary Drug Handbook)

2) "Adverse effects have not been reported in animals." (Saunders Handbook
of Veterinary Drugs)

What part of those references don't you understand?

You want me just to think there is no possible side effect,
no matter how long the medication goes on. *That seems
naive, to say the least.


No- its documented *fact* from highly credible sources.

Everything has side effects.
Maybe it won't be liver damage, or nervous system damage,
or anemia, but you can be sure it will be something.


Do you think you know better than Plumb's and Saunder's? Seems like you
think you do.

Thanks to everyone for your advice. *The cat will receive
interferon for at least the week following his neutering.
After that, I don't know what to do, except look for more
information on the internet,


Here's a better idea: *Buy the fuking books:

*http://www.amazon.com/Plumbs-Veterin.../dp/081380518X

http://www.amazon.com/Saunders-Handb...ch-DACVCP/dp/0...

and get a second opinion.


What will you do when the second vet tells you the same thing?

Trying to get through your think skull is like trying to hammer a rubber
nail through a plank. I know I'm hitting the nail on the head- but it just
bends.


All right. I accept everything you have said, except
the insults, which always could be done without.
  #32  
Old June 7th 09, 10:05 PM posted to rec.pets.cats.health+behav
Calvin
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Posts: 86
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On Jun 7, 10:04*am, "Phil P." wrote:
I'm sorry to say I think your stupidity will kill your cat long before FeLV.


The only thing I've done is reverse the interferon schedule
from 7-days-on/7-days-off, to 7-days-off/7-days-on.
The second period of 7-days-on begins in two days.
I doubt that the week's delay in starting it is going to kill the cat.
There's a difference between discussing and acting.

  #33  
Old June 9th 09, 05:11 PM posted to rec.pets.cats.health+behav
Phil P.
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Posts: 1,027
Default more about interferon side effects


"calvin" wrote in message
...
On Jun 7, 10:04 am, "Phil P." wrote:
I'm sorry to say I think your stupidity will kill your cat long before

FeLV.

The only thing I've done is reverse the interferon schedule
from 7-days-on/7-days-off, to 7-days-off/7-days-on.
The second period of 7-days-on begins in two days.
I doubt that the week's delay in starting it is going to kill the cat.
There's a difference between discussing and acting.


Delaying beginning IFN therapy for a week might not be critical if the
infection has already reached the bone marrow. However, a week's delay in
the early stages of infection might make the difference between
extinguishing an infection or developing a persistent infection for life.
Even though the delay might not be critical, the reason for the delay is.
You delayed treatment because you stubbornly clung to bogus information in
the face of incontrovertible facts to the contrary.


  #34  
Old June 9th 09, 07:00 PM posted to rec.pets.cats.health+behav
Calvin
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Posts: 86
Default more about interferon side effects

On Jun 9, 12:11*pm, "Phil P." wrote:
"calvin" wrote:
On Jun 7, 10:04 am, "Phil P." wrote:
I'm sorry to say I think your stupidity will kill your cat long before
FeLV.

The only thing I've done is reverse the interferon schedule
from 7-days-on/7-days-off, to 7-days-off/7-days-on.
The second period of 7-days-on begins in two days.
I doubt that the week's delay in starting it is going to kill the cat.
There's a difference between discussing and acting.


Delaying beginning IFN therapy for a week might not be critical if the
infection has already reached the bone marrow. *However, a week's delay in
the early stages of infection might make the difference between
extinguishing an infection or developing a persistent infection for life.
Even though the delay might not be critical, the reason for the delay is.
You delayed treatment because you stubbornly clung to bogus information in
the face of incontrovertible facts to the contrary.


Well, I was referring to the delay during the first seven
days of antibiotics. Then the interferon was started
and continued for seven days. The antibiotics concluded
during that period. The following seven days off of the
interferon ended with the cat's neutering yesterday,
and the next seven days on inteferon began today after
I brought him home. That's just to put this back into
perspective.

I'm glad to have seen the good results of the antibiotics
on the cat's skin and fur without having had to wonder
whether the good was done by antibiotics or interferon.

I didn't stubbornly cling to anything. I just wanted to be
sure that I wasn't to be giving the cat something that
would have bad side effects, and I didn't see any reason
why what I read would have been a lie. I didn't know you
from a bump in the road. I finally gave in and did what
you recommended, albeit seven days late; and I recently
capitulated and accepted everything you had said.

Yet you can't resist adding more insults. It appears
that you have some hostility issues.

I'd like to ask a couple of more questions about interferon,
and if you choose to answer them, please do so without
insults:

If it is so harmless, why is it given only during alternate
seven-day periods?

Since this cat eats like a hog, I can be sure that if I put
the interferon on the top of his food he will get it all. He
always cleans his first plate. Is it ok to give the interferon
this way, or should I be squirting it into his mouth directly?
  #35  
Old June 9th 09, 09:18 PM posted to rec.pets.cats.health+behav
Matthew[_3_]
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Posts: 2,287
Default more about interferon side effects

Phil this guy must be slow or have some other problem. This is the first
person in all the years that gives me a headache


"Phil P." wrote in message
news

"calvin" wrote in message
...
On Jun 7, 10:04 am, "Phil P." wrote:
I'm sorry to say I think your stupidity will kill your cat long before

FeLV.

The only thing I've done is reverse the interferon schedule
from 7-days-on/7-days-off, to 7-days-off/7-days-on.
The second period of 7-days-on begins in two days.
I doubt that the week's delay in starting it is going to kill the cat.
There's a difference between discussing and acting.


Delaying beginning IFN therapy for a week might not be critical if the
infection has already reached the bone marrow. However, a week's delay in
the early stages of infection might make the difference between
extinguishing an infection or developing a persistent infection for life.
Even though the delay might not be critical, the reason for the delay is.
You delayed treatment because you stubbornly clung to bogus information in
the face of incontrovertible facts to the contrary.




  #36  
Old June 9th 09, 09:39 PM posted to rec.pets.cats.health+behav
MLB
external usenet poster
 
Posts: 811
Default more about interferon side effects

Matthew wrote:
Phil this guy must be slow or have some other problem. This is the first
person in all the years that gives me a headache


"Phil P." wrote in message
news
"calvin" wrote in message
...
On Jun 7, 10:04 am, "Phil P." wrote:
I'm sorry to say I think your stupidity will kill your cat long before

FeLV.

The only thing I've done is reverse the interferon schedule
from 7-days-on/7-days-off, to 7-days-off/7-days-on.
The second period of 7-days-on begins in two days.
I doubt that the week's delay in starting it is going to kill the cat.
There's a difference between discussing and acting.

Delaying beginning IFN therapy for a week might not be critical if the
infection has already reached the bone marrow. However, a week's delay in
the early stages of infection might make the difference between
extinguishing an infection or developing a persistent infection for life.
Even though the delay might not be critical, the reason for the delay is.
You delayed treatment because you stubbornly clung to bogus information in
the face of incontrovertible facts to the contrary.




er think he might be trolling?
  #37  
Old June 9th 09, 09:53 PM posted to rec.pets.cats.health+behav
Calvin
external usenet poster
 
Posts: 86
Default more about interferon side effects

On Jun 9, 4:39*pm, MLB wrote:
er think he might be trolling?


So far I've spent $241 on vet bills for this stray tomcat.
Expensive trolling, wouldn't you say?
  #38  
Old June 9th 09, 11:14 PM posted to rec.pets.cats.health+behav
Matthew[_3_]
external usenet poster
 
Posts: 2,287
Default more about interferon side effects

When you spend over $10,000 than you can comment about expensive. That was
the cost to save my Rumble and worth every freaking cent.

"calvin" wrote in message
...
On Jun 9, 4:39 pm, MLB wrote:
er think he might be trolling?


So far I've spent $241 on vet bills for this stray tomcat.
Expensive trolling, wouldn't you say?


  #39  
Old June 9th 09, 11:58 PM posted to rec.pets.cats.health+behav
Calvin
external usenet poster
 
Posts: 86
Default more about interferon side effects

On Jun 9, 6:14*pm, "Matthew" wrote:
"calvin" wrote:
So far I've spent $241 on vet bills for this stray tomcat.
Expensive trolling, wouldn't you say?


When you spend over $10,000 than you can comment
about expensive. That was the cost to save my Rumble
and worth every freaking cent.


You don't seem able to grasp the point of anything I say.
I wasn't talking about lifetime vet bills and other cat
expenses. I doubt if you would want to get into that,
or maybe you would because you might think other
people would be impressed by you.

I was talking about money spent during the past three
weeks on a stray tomcat, which would make for
expensive trolling.

Have a nice life. I'm not going to respond to anything
else that you write (or 'cybercat' either, or MLB).

  #40  
Old June 10th 09, 07:32 AM posted to rec.pets.cats.health+behav
Phil P.
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Posts: 1,027
Default more about interferon side effects


"calvin" wrote in message
...
On Jun 9, 12:11 pm, "Phil P." wrote:

I didn't stubbornly cling to anything. I just wanted to be
sure


You should have been sure after I posted excerpts on the safety of IFN from
the 2 top veterinary drug handbooks in your first thread.



Yet you can't resist adding more insults.



I know. I tried really hard to resist- but its just too hard to resist
insulting someone as obtuse as you. I'm sure you're used to it.


It appears
that you have some hostility issues.



Yeah, I know. I've got to try to be more tolerant of obtuse and obstinate
people no matter how aggravating they are. Its on my "to do" list.



If it is so harmless, why is it given only during alternate
seven-day periods?


7 on/7 off has nothing to do with safety. This form of interferon is derived
from human leukocytes, its theroretically possible that cats may develop
anti-IFN antibodies that could inactivate the IFN. However, this has only
occurred in some cats receiving high doses (50,000 IU) SC, IM, or IP.
Anti-IFN antibody production as *never* been documented in cats receiving
low, oral doses-- even cats receiving IFN orally continiously.


Since this cat eats like a hog, I can be sure that if I put
the interferon on the top of his food he will get it all. He
always cleans his first plate. Is it ok to give the interferon
this way, or should I be squirting it into his mouth directly?


Yes- administer the IFN directly into his mouth. *Do not* mix it in the
food. Once again, "Oral interferon works by binding to mucosal receptors in
the oropharynx where it triggers the release of cytokines. The cytokines,
not the interferon, circulate through the system and stimulate the cat's
immune system." If you mix the IFN in the food, it will be digested with the
food and destroyed. The dose is so low, that the IFN must come in direct
contact with the mucosal surfaces in the oropharynx in order to be absorbed.




 




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