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Ketoconazole and Revolution?
I have a kitten on Ketoconazole for ringworm. It's
time for his Revolution application. I can't find any contraindications for using these two drugs at the same time (one post found in google groups suggested both to treat mange), but I'd like to know if anyone has any concerns. The pill is given at the rate of 1/8 of a 200 mg tablet twice daily. More info on the kitten: He's 8 months old, neutered, FeLV+ but otherwise healthy, active, good appetite (I always give him the pill after feeding canned food), playful, healthy coat. He is showing no problems with the pill, and I will take him in to the vet next week to get his blood checked. The bald, crusty spot I found two weeks ago under his right arm was about the size of my palm (average hand size for a female). Now the spot is almost gone. Treatment also includes Melaseb shampoo every 5 days and the topical cream (I forget the name). BTW, his roommate, an 8 month old FeLV+ spayed female has shown no evidence of ringworm, which I find curious (but nice!). Thanks for any help. Gail |
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"Gail Futoran" wrote in message ... I have a kitten on Ketoconazole for ringworm. snip More info on the kitten: He's 8 months old, neutered, FeLV+ *Please* do not use Ketoconazole in your cat. Its an older (20 years) drug and much more toxic to cats than the newer antifungal drugs. Ketoconazole's rep is based on its efficacy in *dogs* (who handle it much better than cats) *not* in cats. Some vets still use Keto in cats because its so cheap compared to Itraconazole (Sporonox) and Fluconazole (Difulcan) which are more effacious and less toxic. "Due to increased toxicity, ketoconazole should not be used in cats." http://www.vin.com/VINDBPub/SearchPB...00/pr00110.htm "Ketoconazole is usually not recommended for cats. Ketoconazole is capable of numerous drug interactions due to inhibition of mammalian cytochrome P-450." http://www.dvmpharmaceuticals.com/dt111.html "Also, the recent limited use of itraconazole in cats indicates that this drug is better tolerated than ketoconazole, in that it appears to be less hepatotoxic" http://www.jaaha.org/cgi/content/full/39/6/543 Itraconazole (ITX) is the drug of choice for ringworm in cats and is a breeze to administer. I found suspending ITZ in butter and giving the pats as a treat was less stressful for the cat than pilling. Most cats just love butter - and the fat increases absorption. I let one of those little resturant-type butter tubs melt down at room temperature, then thoroughly mix the 100 mg capsule in the liquified butter - then refrigerate the tub. When the butter becomes solid, I cut the pat into four or five equal pieces (depending on the cat) - each piece contains an equal amount of drug - i.e., 5 pieces @ 20 mg. A 4 kg (9 lb) cat usually gets 40 mg/day (or whatever my vet prescribes) - so a 9 lb cat gets 2 pieces. I can cut those 2 pieces into smaller pieces if necessary so that the cat can gobble them right down. This method can't be used with all meds, but it works like a charm with ITZ. Lose the Keto. Good luck. Phil. "How long does a cat stretch? From one end of my life to the other" --Me Feline Healthcare - http://maxshouse.com http://groups.yahoo.com/group/Feline..._and_Behavior/ |
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