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#11
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In article , "Jo Firey"
wrote: "Howard C. Berkowitz" wrote in message ... To get more specific into things we actually understand, pain, even if blocked from consciousness but not with full anesthesia, causes the autonomic system to release inflammatory transmitters called prostaglandins -- which cause more pain. The survival benefit of this seemingly perverse mechanism appears to be "self-splinting" by forcing one to hold an injured part rigid. That is one of the most enlightening things I've read in a long time. As in WOW. It is one of my fond hopes that as new doctors are trained and enter practice, there will be more and more knowledge of the science (and art) of pain management. Unfortunately, the understanding of many of the mechanisms of pain are recent enough that older practicing physicians, who don't keep up with current research, simply aren't aware of it. The subspecialty of pain medicine doesn't get the respect it should. Melzack and Wall, who discovered the fundamental mechanism that causes people to become aware of pain, as well as many of the secondary effects of pain transmission, IMNSHO, deserved a Nobel Prize. AFAIK, no pain researcher has ever been in serious consideration for the Nobel Prize in Medicine or Physiology. I have a type of inflammatory arthritis. Now at least I have some understanding of why I have stiff joints. Not the prostaglandins stuff. That I knew. But I'd never heard or thought of the concept of "self splinting". The particular mechanisms I was talking about is directly associated with muscle tissue, but I see no reason why a joint inflammation couldn't cause it. The particular pathway that I was talking about comes from the "lower" brain in response to pain in soft tissue, but the same inflammatory substances are released from arthritic joints. Prostaglandins, incidentally, cause uterine contractions, and they have been used to induce abortion or labor. By taking a prostaglandin antagonist before the crampy stage of the menstrual cycle, so there's a blood level before the prostaglandins hit, often can avoid or minimize cramps. So, the muscles around the joint could go into spasm from the same chemicals, but released from the joint rather than the brain. Ibuprofen, naproxen, and prescription NSAIDs block the enzymes (COX-1 and COX-2) that produces these irritants. Aspirin does as well, but has somewhat different mechanisms. It turns out, however, that not all the products of the two enzymes are bad. Some of the products of COX-1 produce the mucus that normally protects the stomach wall. When you suppress COX-1, you take away protection from acid, which is why aspirin and NSAIDs upset the stomach. The newer selective inhibitors of COX-2 only, such as Vioxx and Celebrex, allow the stomach protection to work normally. Nothing in pain pharmacology tends to be simple. Some people only get pain relief from COX-2 inhibitors, enough that the US Food and Drug Administration approved their being used again, with lots of warning and cardiac monitoring. We understand why COX-2 inhibitors prevent stomach upset, but we are not sure why they are especially effective for pain relief in some, but not all, patients. Like many drugs, there is a delicate balance between risk and benefit. Acetaminophen (Tylenol), or paracetamol across the pond, does not block COX enzymes except in the brain. This is why it has less of a general anti-inflammatory action than the other drugs. It does block pain, however, which, in turn, can block the secondary brain-directed release of prostaglandins in muscle tissue. This may give the effect of decreasing inflammation, but it's really a matter of preventing inflammation. |
#12
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In article , "CatNipped"
wrote: "W. Leong" wrote in message . .. "Jo Firey" wrote in message ... "CatNipped" wrote in message ... Has anyone heard of the above diet book? I have been researching "holistic" things I could do that might help me with my fibromyalgia. Happens that this guy was on "Oprah" on a show about the new anti-aging technology. He claims that the signs of aging are caused buy inflammation at the cellular level" Here's an excerpt from chapter one. "When I wrote The Wrinkle Cure and The Perricone Prescription, I introduced the Inflammation-Aging Connection-the concept that inflammation at the cellular level is the single most powerful cause of the signs of aging. That's not to mention the correlation between inflammation and such chronic diseases as arthritis, diabetes, Alzheimer's, cancer, and strokes. " OK, I don't think a diet is going to make me look like a 30-year-old, but the diet itself isn't a "fad one" - not unreasonable restrictions on fat, carbs, etc. But if there is *anything* to the food-inflammation connection, I got to thinking it might be good, if not for my fibro, then maybe for my degenerative disk disease. In any case he instructs you to eat plenty of foods high in anti-oxidants, avoid sugar, plenty of fresh fruits and veggies, and green tea, so I figure it can't hurt. I ordered the book on Amazon, but was wondering if anyone else had any knowledge or experience with this diet. Hugs, CatNipped You aren't going to find a dietary cure. But the things you mentioned certainly won't hurt you and should make you feel better. I just started the sub-lingual B vitamins someone here mentioned. Way too soon to say they are great, but I did get a lot done the last few days. Another "can't hurt, might help" What is sub-lingual B vitamins? What is the difference between it and 'regular' vitamin B? I have been taking a vitamin B complex pill evey day for years. When I had my gastric bypass surgery they told me that I would either have to get a B Complex vitamin shot every month or take the sub-lingual B Complex vitamins every day - so I'm guessing they're equivalent. I've heard that B vitamins are hard (or maybe impossible?) to absorb through the stomach (Howard?). B12 specifically. For pernicious anemia, which is an inefficiency of the absorption of B12 (a deficiency in something called "intrinsic factor"), the first therapy was eating large amounts of raw liver. While that might be heavenly for a cat, many patients literally preferred to die. Ironically, the Nobel Prize for the treatment of pernicious anemia was given for a slightly more palatable liver extract treatment, before B12 was discovered. Therapy next moved to injected B12. Not all that long ago, it was discovered that even without intrinsic factor, some B12 is absorbed. Treatment of pernicious anemia moved to giving massive overdoses of B12, since there are no known negative side effects to overdoses of any B vitamin except B6. Taking 100mg or so a day of B1, incidentally, will turn urine bright yellow and give a "vitamin" smell to your skin -- but that smell is an excellent insect repellent. With your reduced stomach area, you probably don't have enough surface to absorb adequate B12, even if you have normal intrinsic factor. All I know is that I have *never* had so much energy in my entire life - not even when I was a kid (and that's saying something for a person with ADHD!). ; BTW, you can get the sublingual B Complex vitamins at Walgreens for about $5 for a 2 - 3 month supply. Sublingual drugs pass directly from mouth tissues into the blood, almost as fast as an injection. Nasal sprays are also becoming more common. |
#13
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"Jo Firey" wrote in message ... "CatNipped" wrote in message ... Has anyone heard of the above diet book? In any case he instructs you to eat plenty of foods high in anti-oxidants, avoid sugar, plenty of fresh fruits and veggies, and green tea, so I figure it can't hurt. You aren't going to find a dietary cure. But the things you mentioned certainly won't hurt you and should make you feel better. I just started the sub-lingual B vitamins someone here mentioned. Way too soon to say they are great, but I did get a lot done the last few days. Another "can't hurt, might help" I'm managing to avoid sugar. Wish I could kick white flour. Jo Vitamin B-12 can be very difficult for many people to absorb. Especially those with gastric problems or the elderly. Pills don't help, cause they still can't absorb it that way. I don't know that much about it, but I know my mom got monthly B-12 shots for years after she retired and swore by them. So does my sister-in-law who is an RN who specializes in elder care. Evidently you can absorb it in liquid form under your tongue. I learned that here from CatNipped. So I got some a few days ago at WalMart and have been trying it. It's a not unpleasant tasting liquid and you just put a dropper full under your tongue. Now if I can just get Charlie to try it. Jo |
#14
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CatNipped wrote:
Has anyone heard of the above diet book? No, but I know someone whose last name is Perricone and for a minute I thought maybe you knew her! LOL Jill |
#15
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Sounds like sub-lingual B vitamins has a faster absorption.
I don't even recall why I started taking B vitmain complex, probably on recommendation from a doctor. Think I just stick with my garden variety B complex since I don't have specific needs for it. Besides, no Walgreen in Catnada. Winnie "CatNipped" wrote in message ... "W. Leong" wrote in message . .. "Jo Firey" wrote in message ... "CatNipped" wrote in message ... Has anyone heard of the above diet book? I have been researching "holistic" things I could do that might help me with my fibromyalgia. Happens that this guy was on "Oprah" on a show about the new anti-aging technology. He claims that the signs of aging are caused buy inflammation at the cellular level" Here's an excerpt from chapter one. "When I wrote The Wrinkle Cure and The Perricone Prescription, I introduced the Inflammation-Aging Connection-the concept that inflammation at the cellular level is the single most powerful cause of the signs of aging. That's not to mention the correlation between inflammation and such chronic diseases as arthritis, diabetes, Alzheimer's, cancer, and strokes. " OK, I don't think a diet is going to make me look like a 30-year-old, but the diet itself isn't a "fad one" - not unreasonable restrictions on fat, carbs, etc. But if there is *anything* to the food-inflammation connection, I got to thinking it might be good, if not for my fibro, then maybe for my degenerative disk disease. In any case he instructs you to eat plenty of foods high in anti-oxidants, avoid sugar, plenty of fresh fruits and veggies, and green tea, so I figure it can't hurt. I ordered the book on Amazon, but was wondering if anyone else had any knowledge or experience with this diet. Hugs, CatNipped You aren't going to find a dietary cure. But the things you mentioned certainly won't hurt you and should make you feel better. I just started the sub-lingual B vitamins someone here mentioned. Way too soon to say they are great, but I did get a lot done the last few days. Another "can't hurt, might help" What is sub-lingual B vitamins? What is the difference between it and 'regular' vitamin B? I have been taking a vitamin B complex pill evey day for years. When I had my gastric bypass surgery they told me that I would either have to get a B Complex vitamin shot every month or take the sub-lingual B Complex vitamins every day - so I'm guessing they're equivalent. I've heard that B vitamins are hard (or maybe impossible?) to absorb through the stomach (Howard?). All I know is that I have *never* had so much energy in my entire life - not even when I was a kid (and that's saying something for a person with ADHD!). ; BTW, you can get the sublingual B Complex vitamins at Walgreens for about $5 for a 2 - 3 month supply. Hugs, CatNipped Winnie I'm managing to avoid sugar. Wish I could kick white flour. Jo |
#16
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I haven't heard about this diet specifically, but when Dennis was
still dealing with his back problems, his chiropractor in Bangkok (excellent guy, from California, best chiro ever) recommended for Dennis to eat a "low inflammation" diet. He recommended the same foods you mention and also no caffeine and you should eat half a bag of frozen soy beans (edamame) per day. Dennis never did it because he's a coffee addict, but I fell in love with the edamame and still eat it :-) -- Britta "There is no snooze button on a cat who wants breakfast." -- Unknown Check out pictures of Vino at: http://photos.yahoo.com/badwilson click on the Vino album CatNipped wrote: Has anyone heard of the above diet book? I have been researching "holistic" things I could do that might help me with my fibromyalgia. Happens that this guy was on "Oprah" on a show about the new anti-aging technology. He claims that the signs of aging are caused buy inflammation at the cellular level" Here's an excerpt from chapter one. "When I wrote The Wrinkle Cure and The Perricone Prescription, I introduced the Inflammation-Aging Connection-the concept that inflammation at the cellular level is the single most powerful cause of the signs of aging. That's not to mention the correlation between inflammation and such chronic diseases as arthritis, diabetes, Alzheimer's, cancer, and strokes. " OK, I don't think a diet is going to make me look like a 30-year-old, but the diet itself isn't a "fad one" - not unreasonable restrictions on fat, carbs, etc. But if there is *anything* to the food-inflammation connection, I got to thinking it might be good, if not for my fibro, then maybe for my degenerative disk disease. In any case he instructs you to eat plenty of foods high in anti-oxidants, avoid sugar, plenty of fresh fruits and veggies, and green tea, so I figure it can't hurt. I ordered the book on Amazon, but was wondering if anyone else had a ny knowledge or experience with this diet. Hugs, CatNipped |
#17
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Howard C. Berkowitz wrote:
B12 specifically. For pernicious anemia, which is an inefficiency of the absorption of B12 (a deficiency in something called "intrinsic factor"), the first therapy was eating large amounts of raw liver. While that might be heavenly for a cat, many patients literally preferred to die. Ironically, the Nobel Prize for the treatment of pernicious anemia was given for a slightly more palatable liver extract treatment, before B12 was discovered. Therapy next moved to injected B12. Not all that long ago, it was discovered that even without intrinsic factor, some B12 is absorbed. Treatment of pernicious anemia moved to giving massive overdoses of B12, since there are no known negative side effects to overdoses of any B vitamin except B6. Taking 100mg or so a day of B1, incidentally, will turn urine bright yellow and give a "vitamin" smell to your skin -- but that smell is an excellent insect repellent. With your reduced stomach area, you probably don't have enough surface to absorb adequate B12, even if you have normal intrinsic factor. A few years ago, I decided to take some B12 supplements. Not the sublingual ones, just regular pills. Well, after a few days, I broke out in a nasty itchy rash all over my body. Stopped taking the B12 and the rash went away. Now I just take a regular multivitamin and everything's ok. Weird. -- Britta "There is no snooze button on a cat who wants breakfast." -- Unknown Check out pictures of Vino at: http://photos.yahoo.com/badwilson click on the Vino album |
#18
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In article , "badwilson"
wrote: Howard C. Berkowitz wrote: B12 specifically. For pernicious anemia, which is an inefficiency of the absorption of B12 (a deficiency in something called "intrinsic factor"), the first therapy was eating large amounts of raw liver. While that might be heavenly for a cat, many patients literally preferred to die. Ironically, the Nobel Prize for the treatment of pernicious anemia was given for a slightly more palatable liver extract treatment, before B12 was discovered. Therapy next moved to injected B12. Not all that long ago, it was discovered that even without intrinsic factor, some B12 is absorbed. Treatment of pernicious anemia moved to giving massive overdoses of B12, since there are no known negative side effects to overdoses of any B vitamin except B6. Taking 100mg or so a day of B1, incidentally, will turn urine bright yellow and give a "vitamin" smell to your skin -- but that smell is an excellent insect repellent. With your reduced stomach area, you probably don't have enough surface to absorb adequate B12, even if you have normal intrinsic factor. A few years ago, I decided to take some B12 supplements. Not the sublingual ones, just regular pills. Well, after a few days, I broke out in a nasty itchy rash all over my body. Stopped taking the B12 and the rash went away. Now I just take a regular multivitamin and everything's ok. Weird. Were these white or a clear capsule, or somehow colored? Some dyes used in medications, especially tartrazine (Yellow #5) can trigger asthmatic attacks and have allergic sensitivities. |
#19
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Howard C. Berkowitz wrote:
In article , "badwilson" wrote: Howard C. Berkowitz wrote: B12 specifically. For pernicious anemia, which is an inefficiency of the absorption of B12 (a deficiency in something called "intrinsic factor"), the first therapy was eating large amounts of raw liver. While that might be heavenly for a cat, many patients literally preferred to die. Ironically, the Nobel Prize for the treatment of pernicious anemia was given for a slightly more palatable liver extract treatment, before B12 was discovered. Therapy next moved to injected B12. Not all that long ago, it was discovered that even without intrinsic factor, some B12 is absorbed. Treatment of pernicious anemia moved to giving massive overdoses of B12, since there are no known negative side effects to overdoses of any B vitamin except B6. Taking 100mg or so a day of B1, incidentally, will turn urine bright yellow and give a "vitamin" smell to your skin -- but that smell is an excellent insect repellent. With your reduced stomach area, you probably don't have enough surface to absorb adequate B12, even if you have normal intrinsic factor. A few years ago, I decided to take some B12 supplements. Not the sublingual ones, just regular pills. Well, after a few days, I broke out in a nasty itchy rash all over my body. Stopped taking the B12 and the rash went away. Now I just take a regular multivitamin and everything's ok. Weird. Were these white or a clear capsule, or somehow colored? Some dyes used in medications, especially tartrazine (Yellow #5) can trigger asthmatic attacks and have allergic sensitivities. I don't remember now, it was a few years ago. But I do take a whole bunch of other vitamins and have never had a problem with anything other than B12. -- Britta "There is no snooze button on a cat who wants breakfast." -- Unknown Check out pictures of Vino at: http://photos.yahoo.com/badwilson click on the Vino album |
#20
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On 2005-08-04, Howard C. Berkowitz penned:
Prostaglandins, incidentally, cause uterine contractions, and they have been used to induce abortion or labor. By taking a prostaglandin antagonist before the crampy stage of the menstrual cycle, so there's a blood level before the prostaglandins hit, often can avoid or minimize cramps. Er, where did you say I could get this stuff, again? After years of Depo (no period, so no cramps), cramps are back in my life, about as welcome as a long-lost creditor. -- monique, who spoils Oscar unmercifully pictures: http://www.bounceswoosh.org/rpca |
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