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#1
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Flea & Tick Control?
Hi,
I have 2 adolescent cats (about 22 weeks old) and they're going outside now. I wanted to get some kind of flea & tick control for them. My Vet recommended Frontline and said that the over the counter stuff could cause neurological damage. In reading about Frontline, I found some dogs that had adverse reactions, including one that apparently died when the product was used in conjunction with other flea & tick control products. So the question is this: how safe is Frontline? Is the claim about other medications being less safe accurate? What have your experiences with flea & tick control been? Favorite products? Tips? Things I should keep in mind? Thanks! |
#2
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In article , xmp333
@yahoo.com enlightened us with... Hi, I have 2 adolescent cats (about 22 weeks old) and they're going outside now. I wanted to get some kind of flea & tick control for them. My Vet recommended Frontline and said that the over the counter stuff could cause neurological damage. It's a poison. All flea and tick meds are to some degree. You risk it because it's worse for the cat to have fleas and ticks than to take the meds. I have heard some horrible things about Hartz - stay away from that stuff. I use Advantix on my dog, but never, ever use that on a cat. Very bad for them. Can kill them. My cats stay inside or with me on leash, so I don't give them flea and tick treatments. I live in an urban area, so I've not had a problem with this. The dog gets it because she goes to the forest preserves and such. Are you SURE you live where it is safe to let your cats out (maybe they are just in an enclosure or your yard)? Do you have them microchipped in case they get lost? Collars and tags can come off - chips are there forever. Don't forget that sometimes, the greatest danger to an outide cat is a human! -- -- ~kaeli~ Is it possible to be totally partial? http://www.ipwebdesign.net/wildAtHeart http://www.ipwebdesign.net/kaelisSpace |
#3
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In article , xmp333
@yahoo.com enlightened us with... Hi, I have 2 adolescent cats (about 22 weeks old) and they're going outside now. I wanted to get some kind of flea & tick control for them. My Vet recommended Frontline and said that the over the counter stuff could cause neurological damage. It's a poison. All flea and tick meds are to some degree. You risk it because it's worse for the cat to have fleas and ticks than to take the meds. I have heard some horrible things about Hartz - stay away from that stuff. I use Advantix on my dog, but never, ever use that on a cat. Very bad for them. Can kill them. My cats stay inside or with me on leash, so I don't give them flea and tick treatments. I live in an urban area, so I've not had a problem with this. The dog gets it because she goes to the forest preserves and such. Are you SURE you live where it is safe to let your cats out (maybe they are just in an enclosure or your yard)? Do you have them microchipped in case they get lost? Collars and tags can come off - chips are there forever. Don't forget that sometimes, the greatest danger to an outide cat is a human! -- -- ~kaeli~ Is it possible to be totally partial? http://www.ipwebdesign.net/wildAtHeart http://www.ipwebdesign.net/kaelisSpace |
#4
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wrote in message
om... Is the claim about other medications being less safe accurate? What have your experiences with flea & tick control been? Favorite products? Tips? Things I should keep in mind? I have used Frontline on my dog before and it worked fine, but that was on a dog. A few years ago I was found a stray cat and brought him home. He had flees and I used Advantix on my cats. At the time I had five. Within thirty minutes, one of them was convulsing on floor, one was rolling around drooling, one had a twitch in his eye, and two of them were fine. I took the three that were affected to the vet, they did not think one of them was going to make it. The Vet told me that he had seen Advantix have this reaction on cats before. In the end it all worked out fine and they are all ok today. There are other ways to take care of the flees with out killing the cats. |
#5
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wrote in message
om... Is the claim about other medications being less safe accurate? What have your experiences with flea & tick control been? Favorite products? Tips? Things I should keep in mind? I have used Frontline on my dog before and it worked fine, but that was on a dog. A few years ago I was found a stray cat and brought him home. He had flees and I used Advantix on my cats. At the time I had five. Within thirty minutes, one of them was convulsing on floor, one was rolling around drooling, one had a twitch in his eye, and two of them were fine. I took the three that were affected to the vet, they did not think one of them was going to make it. The Vet told me that he had seen Advantix have this reaction on cats before. In the end it all worked out fine and they are all ok today. There are other ways to take care of the flees with out killing the cats. |
#6
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I've used Advantage and Program with no negative side effects on a few
different animals. The Advantage kills the fleas the program stops the fleas from reproducing. W wrote in message om... Hi, I have 2 adolescent cats (about 22 weeks old) and they're going outside now. I wanted to get some kind of flea & tick control for them. My Vet recommended Frontline and said that the over the counter stuff could cause neurological damage. In reading about Frontline, I found some dogs that had adverse reactions, including one that apparently died when the product was used in conjunction with other flea & tick control products. So the question is this: how safe is Frontline? Is the claim about other medications being less safe accurate? What have your experiences with flea & tick control been? Favorite products? Tips? Things I should keep in mind? Thanks! |
#7
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I've used Advantage and Program with no negative side effects on a few
different animals. The Advantage kills the fleas the program stops the fleas from reproducing. W wrote in message om... Hi, I have 2 adolescent cats (about 22 weeks old) and they're going outside now. I wanted to get some kind of flea & tick control for them. My Vet recommended Frontline and said that the over the counter stuff could cause neurological damage. In reading about Frontline, I found some dogs that had adverse reactions, including one that apparently died when the product was used in conjunction with other flea & tick control products. So the question is this: how safe is Frontline? Is the claim about other medications being less safe accurate? What have your experiences with flea & tick control been? Favorite products? Tips? Things I should keep in mind? Thanks! |
#8
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From:
So the question is this: how safe is Frontline? Is the claim about other medications being less safe accurate? Here's a bit of information: ADVANTAGE: ---Imidacloprid is quickly and almost completely absorbed from the gastrointestinal tract, and eliminated via urine and feces (70-80% and 20-30%, respectively, of the 96% of the parent compound administered within 48 hours). The most important metabolic steps include the degradation to 6-chloronicotinic acid, a compound that acts on the nervous system as described above. This compound may be conjugated with glycine and eliminated, or reduced to guanidine. (Kidd, 1991) --- U of Guelph: ---chlorinated derivatives of nicotine (imidacloprid, fipronil) While the effects of cholinesterase inhibiting products are intended for insect pests, these chemicals can also be poisonous, or toxic, to humans in some situations. --- ----Adverse Effects of Ingredients Found in Spot-On Products Imidacloprid - Active Carcinogen - Yet to be determined; evidence of thyroid lesions in dogs Organ damage - Liver, kidney, thyroid, heart, lungs, spleen, adrenal, brain, gonads; liver toxicity, increased organ weights, thyroid lesions, increased cholesterol levels in dogs Neurotoxin - Incoordination and labored breathing, muscle weakness including muscles necessary for breathing Teratogen - Increased miscarriages and smaller offspring How does Advantage work? The active ingredient in Advantage is imidacloprid, a new compound which has never been used in animal health. Unlike organophosphates and carbamates which inhibit cholinesterase and pyrethrins that block open ion channels along nerve fibers, imidacloprid binds to nicotinyl receptor sites on the postsynaptic neuron which prevents the binding of acetylcholine. This action interupts nerve transmission and results in paralysis and death of the flea. This mechanism of action is entirely new to animal health and the possibility of cross resistance with other flea control chemistry is unlikely. Advantage kills fleas on contact which differentiates it from insect growth regulators and insect development inhibitors which have no effect on the viability of adult fleas. How is Advantage distributed on the animal? Advantage is distributed to all parts of the body where fleas are found. Advantage spreads on the surface of skin at the hair root level aided by body movement providing complete coverage. Advantage is not absorbed into the blood stream or internal organs. How is Advantage applied? Advantage is easy to apply. The seal of the Advantage applicator is broken and the low volume dose is placed directly against the skin between the shoulder blades of dogs and at the base of the skull on cats. Dogs that weigh more than 55 lbs receive the contents of two Advantage 55 tubes. One is placed between the shoulder blades and a second is applied on the top of the rump. http://www.vspn.org/VSPNSearch/VINLibrary/lv960042.htm Imidacloprid Imidacloprid (Advantage) was originally used for crop pest control, and is approved for use in dogs and cats. It works on contact by preventing transmission of neuro-impulses, resulting in death of the adult flea. Imidacloprid is not effective against ticks. Imidacloprid is applied monthly as a pour-on. Within 24 hours after application, it is evenly distributed over the body, with no systemic absorption. It has no repellent activity, and is not inactivated by sunlight. It is partially removed by swimming and bathing. Imidacloprid has low toxicity in mammals, and is safe in the environment. http://www.cm-d.com/buckeye/tech_manual/8_47.html : J Toxicol Clin Toxicol. 2001;39(6):617-21. Related Articles, Links Acute poisoning with the neonicotinoid insecticide imidacloprid in N-methyl pyrrolidone. Wu IW, Lin JL, Cheng ET. Chang Gun Memorial Hospital, Lin-Kuo Medical Center, Taipei, Taiwan, Republic of China. BACKGROUND: Imidacloprid [1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylideneamine, CAS 138261-41-3] belongs to a relatively new class of insecticidal chemistry, the chloronicotinyl neonicotinoid compounds. Animal studies indicate relatively low toxicity to mammals because they have resistant nicotinic receptor subtypes compared to insects, as well as protection of the central nervous system by the blood brain barrier. Despite wide usage, human exposure experience resulting in toxicity is quite limited. CASE REPORT: Here, we report a case of acute ingestion of an insecticide formulation containing 9.7% imidacloprid, 2 % surfactant, and the balance as solvent, N-methyl pyrrolidone. Clinical manifestation included drowsiness, disorientation, dizziness, oral and gastroesophageal erosions, hemorrhagic gastritis, productive cough, fever, leukocytosis, and hyperglycemia. The patient recovered without complication with supportive treatment and was discharged 4 days after ingestion. Follow-up barium upper gastrointestinal examination 1 month later was normal. Because moderate to high dose imidacloprid in animals causes central nervous system activation similar to nicotine, including tremors, impaired pupillary function, and hypothermia, it is unclear whether imidacloprid had a causal role in the patient's initial drowsiness and dizziness. It is more likely that the formulation ingredients, particularly N-methyl pyrrolidone, caused most of the clinical symptoms including minor central nervous system depression, gastrointestinal irritation, and hyperglycemia. PMID: 11762670 [PubMed - indexed for MEDLINE] 1: Mol Cell Biochem. 1997 Apr;169(1-2):177-84. Related Articles, Links Determination of genotoxicity of the metabolites of the pesticides Guthion, Sencor, Lorox, Reglone, Daconil and Admire by 32P-postlabeling. Shah RG, Lagueux J, Kapur S, Levallois P, Ayotte P, Tremblay M, Zee J, Poirier GG. Unit of Health and Environment, CHUL Research Center, Ste-Foy, Quebec, Canada. Commercial formulations of the pesticides: Guthion (azinphos methyl), Sencor (metribuzin), Lorox (linuron), Reglone (diquat), Daconil (chlorothalonil) and Admire (imidacloprid) were studied for their genotoxicity by 32P-postlabeling. Metabolites of the pesticides were obtained enzymatically using arochlor induced rat liver S9 fraction, in an NADPH generating system. The resulting metabolites were reacted with calf thymus DNA and the DNA was analyzed for presence of adducts by either the nuclease P1 or butanol enrichment. Nuclease P1 enrichment resulted in adducts for all the pesticides. Compared to the level of adducts in control DNA, the levels in pesticide-treated DNA were higher for all the pesticides, except Daconil. The increase in adduct numbers for pesticide-treated DNAs ranged from 4.9-12.4 times the control-DNA indicating pesticide genotoxicity in this in vitro system. Enrichment using butanol extraction gave three adducts unique to Sencor-DNA. These adducts were different from those obtained with nuclease P1 enrichment of the same. B(alpha)P was the positive control for the in vitro metabolism, and two adduct enrichment procedures: nuclease P1 digestion and butanol extraction. PMID: 9089646 [PubMed - indexed for MEDLINE] FRONTLINE: ---Adverse Reactions, Australia http://www.apvma.gov.au/qa/aer96.shtml lips the same day as treatment with the product (Vet. nurse developed lip blisters the next day; veterinarian and nurse both had asthma attacks) Registrant reports that some asthmatic cats have developed signs after being sprayed, particularly in confined spaces. Some animals have developed a localised type 1 hypersensitivity after spraying with product, with evidence of hyperaemia, pruritis and pin point blisters like sunburn --- Fipronil - Active Carcinogen - Thyroid cancer (possible human carcinogen) Organ damage - Increased organ weights, altered thyroid hormones Neurotoxin (nervous system damage) - Loss of appetite, underactivity, convulsions, whining, barking, crying (vocalization), body twitches/tremors, overactivity, salivation, stiffened limbs, unsteady gait, incoordination, labored breathing Teratogen (reproductive damage) - Reduced fertility, decreased litter size and body weights in litters, fetus mortality Skin problems - Severe moist inflammation, ulcerations, skin sloughing, chemical burn, itching, LUFENURON (Program) [PDF] Adverse reactions to veterinary drugs reported in Sweden during ... File Format: PDF/Adobe Acrobat .... In another report, vomiting was observed after treatment with lufenuron. .... strengthened if several reports are obtained describing the same adverse reaction. ... www.blackwell-synergy.com/links/doi/10.1046/ j.1365-2885.1997.00050.x/abs/ [PDF] REPORT OF ADVERSE EXPERIENCES 1997 AND 1998 File Format: PDF/Adobe Acrobat - View as HTML .... the clinical signs, so the reaction was classified ... cats and subsequent suspected adverse reactions during ... containing the active constituent lufenuron used in a ... www.apvma.gov.au/qa/aer9798.pdf - http://www.fluoridealert.org/pestici...nuron-page.htm Lufenuron7. Canadian Ministry report on rejection due to residues in poultry breast meat. - Ontario Agriculture, Food, and Rural Affairs (Canada) Current Uses in Pets: FDA registered because it was given orally and absorbed systemically. Warning from Pet Consumer Report. Australia: "Current List. RECORD OF APPROVED ACTIVE CONSTITUENTS FOR CHEMICAL PRODUCTS." December 10, 2001. Also at: http://www.nra.gov.au/tgac/tgac.pdf Glossary of Pesticide Chemicals, October 2001. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. Also available at: http://vm.cfsan.fda.gov/~acrobat/pestglos.pdf ---Lufenuron: Warning from Pet Consumer Report. -------------------------------------------------------------------------- ------ http://www.petconsumerreport.com/sentinel.htm Warning about Sentinel and other Flea and Heartworm Products Is Sentinel the Answer to Heartworm and Fleas? Sentinel is a monthly tablet that guards against heartworm, fleas, roundworm, hookworm and whipworm. Wow! Now that's a mouth full! Seems like an easy answer to all your prayers, right? Are you wondering how one little pill can do all this? Well the answer is simple and straight forward; it poisens heartworm, fleas, roundworm, hookworm and whipworm. Actually, it's enough poison to kill an army of insects and parasites. But it is FDA approved and the FDA says it is harmless to dogs. So, is it "safe" to trust the FDA when it comes to your pet? Well, keep in mind this is the same organization that approved PPA in all of our cold medications that is getting so much media attention and the basis of hundreds of lawsuits. Don't put the health of your dog or cat in the government's hands -- we wouldn't. As always, we encourage you to get the facts and decide for yourself. One of the chemicals Sentinel contains, lufenuron, is used for the flea prevention. Unfortunately, it doesn't prevent fleas from jumping on your pet. Lufenuron has no effect at all on the adult flea, as a matter of fact, its only target is the female flea who lays eggs. When a female flea jumps on and bites a treated pet it ingests lufenuron. When the female lays eggs, the lufenuron is deposited in her eggs. Now here is the clincher. Sentinel states that lufenuron prevents "most" eggs from hatching or maturing into adults. Most? What about the fleas that do not fit into this "most" category? And what about all the male fleas? Well logically, they remain on the animal. You know what it recommends on the package? "Use of other conventional insecticides should be employed for adult flea prevention." If you do that, why even use Sentinel? We consider this pill an internal insecticide. Side Effects of Sentinel Want more? Let's take a look at some of the side effects of Sentinel. It has been reported to cause lack of appetite and anorexia, vomiting, diarrhea, convulsions, lethargy, difficulty breathing, and skin irritations. Hmm, a long list of side effects just like a long list of what Sentinel prevents. When these products first came out, the EPA (Environmental Protection Agency) became flooded with reports of adverse side effects. Apparently the pesticides and repellents being used to protect dogs and cats from fleas, ticks and parasites were harming the health of the animals and the humans administering them. That's right, humans! In an 18-month period the EPA received 853 reports of adverse side effects caused from these so-called "safe, easy to use monthly tablets". There were 148 animal deaths, and 58 reports of human sickness. Doesn't sound too safe to us! Think about this -- those are just the people who made the association between their personal or pet's illness with Sentinel. Most people would not even think of this potentially making them sick because it is marketed as totally safe. Animal Right Issues We have a real issue here too. At the time this article was written, Novartis Animal Health, the makers of Sentinel, use laboratory animals to test their products. They purposely overdose innocent dogs and cats to see what will happen. They give high doses to pregnant dogs to see if there are any birth defects passed to the puppies. They administer "exaggerated doses" to puppies to see if they develop any side effects. All this from a company who puts the words "animal health" after their name. Why would a company so concerned about animal health put animal's health in jeopardy? We will never have a good answer for that one. More Heartworm and Parasite Remedies Solutions Discussed In-Depth @ AOL's Member Community- get 1000 hours free to try! Petagonia.com holistic pet health portal Petagonia.com holistic animal welfare portal---- Some reported Adverse Reactions to Injectable Lufenuron Pain on injection, tenderness, twitching or fractious during injection Lump or granuloma Vomiting Listlessness/Lethargy Diarrhea Anorexia Ferret FAQ - Part 4 of 5 .... Like any other animals, ferrets occasionally have adverse reactions to ... Program is used at the cat dosage per pound ... in the blood and prevents fleas which have .... www.ferretcentral.org/faq/part4.html Organophosphate Poisoning .... their experience as a 'Suspected Adverse Reaction' (SAR) to ... alternative to the flea problem, 'Program' (lenfuron) taken ... It did not kill fleas but stopped them .... www.positivehealth.com/permit/Articles/ Environment/organo.htm Lauren ________ See my cats: http://community.webshots.com/album/56955940rWhxAe Raw Diet Info: http://www.holisticat.com/drjletter.html http://www.geocities.com/rawfeeders/ForCatsOnly.html Declawing Info: http://www.wholecat.com/articles/claws.htm |
#9
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From:
So the question is this: how safe is Frontline? Is the claim about other medications being less safe accurate? Here's a bit of information: ADVANTAGE: ---Imidacloprid is quickly and almost completely absorbed from the gastrointestinal tract, and eliminated via urine and feces (70-80% and 20-30%, respectively, of the 96% of the parent compound administered within 48 hours). The most important metabolic steps include the degradation to 6-chloronicotinic acid, a compound that acts on the nervous system as described above. This compound may be conjugated with glycine and eliminated, or reduced to guanidine. (Kidd, 1991) --- U of Guelph: ---chlorinated derivatives of nicotine (imidacloprid, fipronil) While the effects of cholinesterase inhibiting products are intended for insect pests, these chemicals can also be poisonous, or toxic, to humans in some situations. --- ----Adverse Effects of Ingredients Found in Spot-On Products Imidacloprid - Active Carcinogen - Yet to be determined; evidence of thyroid lesions in dogs Organ damage - Liver, kidney, thyroid, heart, lungs, spleen, adrenal, brain, gonads; liver toxicity, increased organ weights, thyroid lesions, increased cholesterol levels in dogs Neurotoxin - Incoordination and labored breathing, muscle weakness including muscles necessary for breathing Teratogen - Increased miscarriages and smaller offspring How does Advantage work? The active ingredient in Advantage is imidacloprid, a new compound which has never been used in animal health. Unlike organophosphates and carbamates which inhibit cholinesterase and pyrethrins that block open ion channels along nerve fibers, imidacloprid binds to nicotinyl receptor sites on the postsynaptic neuron which prevents the binding of acetylcholine. This action interupts nerve transmission and results in paralysis and death of the flea. This mechanism of action is entirely new to animal health and the possibility of cross resistance with other flea control chemistry is unlikely. Advantage kills fleas on contact which differentiates it from insect growth regulators and insect development inhibitors which have no effect on the viability of adult fleas. How is Advantage distributed on the animal? Advantage is distributed to all parts of the body where fleas are found. Advantage spreads on the surface of skin at the hair root level aided by body movement providing complete coverage. Advantage is not absorbed into the blood stream or internal organs. How is Advantage applied? Advantage is easy to apply. The seal of the Advantage applicator is broken and the low volume dose is placed directly against the skin between the shoulder blades of dogs and at the base of the skull on cats. Dogs that weigh more than 55 lbs receive the contents of two Advantage 55 tubes. One is placed between the shoulder blades and a second is applied on the top of the rump. http://www.vspn.org/VSPNSearch/VINLibrary/lv960042.htm Imidacloprid Imidacloprid (Advantage) was originally used for crop pest control, and is approved for use in dogs and cats. It works on contact by preventing transmission of neuro-impulses, resulting in death of the adult flea. Imidacloprid is not effective against ticks. Imidacloprid is applied monthly as a pour-on. Within 24 hours after application, it is evenly distributed over the body, with no systemic absorption. It has no repellent activity, and is not inactivated by sunlight. It is partially removed by swimming and bathing. Imidacloprid has low toxicity in mammals, and is safe in the environment. http://www.cm-d.com/buckeye/tech_manual/8_47.html : J Toxicol Clin Toxicol. 2001;39(6):617-21. Related Articles, Links Acute poisoning with the neonicotinoid insecticide imidacloprid in N-methyl pyrrolidone. Wu IW, Lin JL, Cheng ET. Chang Gun Memorial Hospital, Lin-Kuo Medical Center, Taipei, Taiwan, Republic of China. BACKGROUND: Imidacloprid [1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylideneamine, CAS 138261-41-3] belongs to a relatively new class of insecticidal chemistry, the chloronicotinyl neonicotinoid compounds. Animal studies indicate relatively low toxicity to mammals because they have resistant nicotinic receptor subtypes compared to insects, as well as protection of the central nervous system by the blood brain barrier. Despite wide usage, human exposure experience resulting in toxicity is quite limited. CASE REPORT: Here, we report a case of acute ingestion of an insecticide formulation containing 9.7% imidacloprid, 2 % surfactant, and the balance as solvent, N-methyl pyrrolidone. Clinical manifestation included drowsiness, disorientation, dizziness, oral and gastroesophageal erosions, hemorrhagic gastritis, productive cough, fever, leukocytosis, and hyperglycemia. The patient recovered without complication with supportive treatment and was discharged 4 days after ingestion. Follow-up barium upper gastrointestinal examination 1 month later was normal. Because moderate to high dose imidacloprid in animals causes central nervous system activation similar to nicotine, including tremors, impaired pupillary function, and hypothermia, it is unclear whether imidacloprid had a causal role in the patient's initial drowsiness and dizziness. It is more likely that the formulation ingredients, particularly N-methyl pyrrolidone, caused most of the clinical symptoms including minor central nervous system depression, gastrointestinal irritation, and hyperglycemia. PMID: 11762670 [PubMed - indexed for MEDLINE] 1: Mol Cell Biochem. 1997 Apr;169(1-2):177-84. Related Articles, Links Determination of genotoxicity of the metabolites of the pesticides Guthion, Sencor, Lorox, Reglone, Daconil and Admire by 32P-postlabeling. Shah RG, Lagueux J, Kapur S, Levallois P, Ayotte P, Tremblay M, Zee J, Poirier GG. Unit of Health and Environment, CHUL Research Center, Ste-Foy, Quebec, Canada. Commercial formulations of the pesticides: Guthion (azinphos methyl), Sencor (metribuzin), Lorox (linuron), Reglone (diquat), Daconil (chlorothalonil) and Admire (imidacloprid) were studied for their genotoxicity by 32P-postlabeling. Metabolites of the pesticides were obtained enzymatically using arochlor induced rat liver S9 fraction, in an NADPH generating system. The resulting metabolites were reacted with calf thymus DNA and the DNA was analyzed for presence of adducts by either the nuclease P1 or butanol enrichment. Nuclease P1 enrichment resulted in adducts for all the pesticides. Compared to the level of adducts in control DNA, the levels in pesticide-treated DNA were higher for all the pesticides, except Daconil. The increase in adduct numbers for pesticide-treated DNAs ranged from 4.9-12.4 times the control-DNA indicating pesticide genotoxicity in this in vitro system. Enrichment using butanol extraction gave three adducts unique to Sencor-DNA. These adducts were different from those obtained with nuclease P1 enrichment of the same. B(alpha)P was the positive control for the in vitro metabolism, and two adduct enrichment procedures: nuclease P1 digestion and butanol extraction. PMID: 9089646 [PubMed - indexed for MEDLINE] FRONTLINE: ---Adverse Reactions, Australia http://www.apvma.gov.au/qa/aer96.shtml lips the same day as treatment with the product (Vet. nurse developed lip blisters the next day; veterinarian and nurse both had asthma attacks) Registrant reports that some asthmatic cats have developed signs after being sprayed, particularly in confined spaces. Some animals have developed a localised type 1 hypersensitivity after spraying with product, with evidence of hyperaemia, pruritis and pin point blisters like sunburn --- Fipronil - Active Carcinogen - Thyroid cancer (possible human carcinogen) Organ damage - Increased organ weights, altered thyroid hormones Neurotoxin (nervous system damage) - Loss of appetite, underactivity, convulsions, whining, barking, crying (vocalization), body twitches/tremors, overactivity, salivation, stiffened limbs, unsteady gait, incoordination, labored breathing Teratogen (reproductive damage) - Reduced fertility, decreased litter size and body weights in litters, fetus mortality Skin problems - Severe moist inflammation, ulcerations, skin sloughing, chemical burn, itching, LUFENURON (Program) [PDF] Adverse reactions to veterinary drugs reported in Sweden during ... File Format: PDF/Adobe Acrobat .... In another report, vomiting was observed after treatment with lufenuron. .... strengthened if several reports are obtained describing the same adverse reaction. ... www.blackwell-synergy.com/links/doi/10.1046/ j.1365-2885.1997.00050.x/abs/ [PDF] REPORT OF ADVERSE EXPERIENCES 1997 AND 1998 File Format: PDF/Adobe Acrobat - View as HTML .... the clinical signs, so the reaction was classified ... cats and subsequent suspected adverse reactions during ... containing the active constituent lufenuron used in a ... www.apvma.gov.au/qa/aer9798.pdf - http://www.fluoridealert.org/pestici...nuron-page.htm Lufenuron7. Canadian Ministry report on rejection due to residues in poultry breast meat. - Ontario Agriculture, Food, and Rural Affairs (Canada) Current Uses in Pets: FDA registered because it was given orally and absorbed systemically. Warning from Pet Consumer Report. Australia: "Current List. RECORD OF APPROVED ACTIVE CONSTITUENTS FOR CHEMICAL PRODUCTS." December 10, 2001. Also at: http://www.nra.gov.au/tgac/tgac.pdf Glossary of Pesticide Chemicals, October 2001. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. Also available at: http://vm.cfsan.fda.gov/~acrobat/pestglos.pdf ---Lufenuron: Warning from Pet Consumer Report. -------------------------------------------------------------------------- ------ http://www.petconsumerreport.com/sentinel.htm Warning about Sentinel and other Flea and Heartworm Products Is Sentinel the Answer to Heartworm and Fleas? Sentinel is a monthly tablet that guards against heartworm, fleas, roundworm, hookworm and whipworm. Wow! Now that's a mouth full! Seems like an easy answer to all your prayers, right? Are you wondering how one little pill can do all this? Well the answer is simple and straight forward; it poisens heartworm, fleas, roundworm, hookworm and whipworm. Actually, it's enough poison to kill an army of insects and parasites. But it is FDA approved and the FDA says it is harmless to dogs. So, is it "safe" to trust the FDA when it comes to your pet? Well, keep in mind this is the same organization that approved PPA in all of our cold medications that is getting so much media attention and the basis of hundreds of lawsuits. Don't put the health of your dog or cat in the government's hands -- we wouldn't. As always, we encourage you to get the facts and decide for yourself. One of the chemicals Sentinel contains, lufenuron, is used for the flea prevention. Unfortunately, it doesn't prevent fleas from jumping on your pet. Lufenuron has no effect at all on the adult flea, as a matter of fact, its only target is the female flea who lays eggs. When a female flea jumps on and bites a treated pet it ingests lufenuron. When the female lays eggs, the lufenuron is deposited in her eggs. Now here is the clincher. Sentinel states that lufenuron prevents "most" eggs from hatching or maturing into adults. Most? What about the fleas that do not fit into this "most" category? And what about all the male fleas? Well logically, they remain on the animal. You know what it recommends on the package? "Use of other conventional insecticides should be employed for adult flea prevention." If you do that, why even use Sentinel? We consider this pill an internal insecticide. Side Effects of Sentinel Want more? Let's take a look at some of the side effects of Sentinel. It has been reported to cause lack of appetite and anorexia, vomiting, diarrhea, convulsions, lethargy, difficulty breathing, and skin irritations. Hmm, a long list of side effects just like a long list of what Sentinel prevents. When these products first came out, the EPA (Environmental Protection Agency) became flooded with reports of adverse side effects. Apparently the pesticides and repellents being used to protect dogs and cats from fleas, ticks and parasites were harming the health of the animals and the humans administering them. That's right, humans! In an 18-month period the EPA received 853 reports of adverse side effects caused from these so-called "safe, easy to use monthly tablets". There were 148 animal deaths, and 58 reports of human sickness. Doesn't sound too safe to us! Think about this -- those are just the people who made the association between their personal or pet's illness with Sentinel. Most people would not even think of this potentially making them sick because it is marketed as totally safe. Animal Right Issues We have a real issue here too. At the time this article was written, Novartis Animal Health, the makers of Sentinel, use laboratory animals to test their products. They purposely overdose innocent dogs and cats to see what will happen. They give high doses to pregnant dogs to see if there are any birth defects passed to the puppies. They administer "exaggerated doses" to puppies to see if they develop any side effects. All this from a company who puts the words "animal health" after their name. Why would a company so concerned about animal health put animal's health in jeopardy? We will never have a good answer for that one. More Heartworm and Parasite Remedies Solutions Discussed In-Depth @ AOL's Member Community- get 1000 hours free to try! Petagonia.com holistic pet health portal Petagonia.com holistic animal welfare portal---- Some reported Adverse Reactions to Injectable Lufenuron Pain on injection, tenderness, twitching or fractious during injection Lump or granuloma Vomiting Listlessness/Lethargy Diarrhea Anorexia Ferret FAQ - Part 4 of 5 .... Like any other animals, ferrets occasionally have adverse reactions to ... Program is used at the cat dosage per pound ... in the blood and prevents fleas which have .... www.ferretcentral.org/faq/part4.html Organophosphate Poisoning .... their experience as a 'Suspected Adverse Reaction' (SAR) to ... alternative to the flea problem, 'Program' (lenfuron) taken ... It did not kill fleas but stopped them .... www.positivehealth.com/permit/Articles/ Environment/organo.htm Lauren ________ See my cats: http://community.webshots.com/album/56955940rWhxAe Raw Diet Info: http://www.holisticat.com/drjletter.html http://www.geocities.com/rawfeeders/ForCatsOnly.html Declawing Info: http://www.wholecat.com/articles/claws.htm |
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From: "medicscout"
I have used Frontline on my dog before and it worked fine, but that was on a dog. A few years ago I was found a stray cat and brought him home. He had flees and I used Advantix on my cats. At the time I had five. Within thirty minutes, one of them was convulsing on floor, one was rolling around drooling, one had a twitch in his eye, and two of them were fine. I took the three that were affected to the vet, they did not think one of them was going to make it. The Vet told me that he had seen Advantix have this reaction on cats before. In the end it all worked out fine and they are all ok today. There are other ways to take care of the flees with out killing the cats. Here's some information on Revolution as reported to the FDA: from Veterinary Adverse Reaction Reports June 2003 www.fda.gov Revolution/SELAMECTIN, Topical Application Treated -3472 Reacted -3043 Died - 208 Reactions: KIDNEY FAILURE MELENA PARESIS, HIND LIMB(S) PRURITIS, EAR(S) RADIOGRAPH(S) ABN ULCER(S), SKIN CONFUSION CPK HI, BLD EDEMA, HEAD/FACE HEAD TILT INEFFECT, STRONGYLES PALLOR, MUCOUS MEMBRAN PD-UNDERFILL, TUBE(S) PR-LIVER, LESION(S) TACHYCARDIA URTICARIA AGGRESSION ALBUMIN LO, BLD COLLAPSE HAIR, SHEDDING ICTERUS ILL LAMENESS P HI, BLD POLYURIA SCALE(S), SKIN SEGS HI, BLD APPLICATION SITE HAIR, ABN CIRCLING EDEMA, LUNG(S)/TRACHEA GLUCOSE LO, BLD HEMATOCHEZIA LICKING PAIN PARESIS PROLAPSE, THIRD EYELID RASH SHAKING SORE(S) STUPOR TOPICAL, CAT SELAMECTIN Reactions: ADIPSIA AMYLASE HI, BLD ANISOCORIA APPLICATION SITE SWELLING APPREHENSION BITING/CHEWING BLEPHAROSPASM DEATH(NEWBORN) DISCHARGE, EYE(S)/LID(S) DISCHARGE, NOSE ENLARGEMENT, LYMPH NOD GLUCOSE HI, BLD INEFFECT, ASCARIDS PRE INEFFECT, HW LARVAE LIVER ENZYMES HI, BLD MORIBUND SWELLING, HEAD/FACE UNCONSCIOUS APPLICATION SITE ABNORMAL BRADYCARDIA CONGESTION, EAR(S) DIARRHEA, WATERY EPIPHORA GAGGING GLOBULIN HI, BLD HAIR, ABN HYPERESTHESIA IRRITATION, SKIN K HI, BLD NA LO, BLD OTITIS PAIN, ABDOMEN PALLOR PD-ODOR, ABN PROTEIN(TOT) HI, BLD SOMNOLENCE URINATION ABN VOMITING, BLOODY BREATHING ABN CA HI, BLD TOPICAL, CAT SELAMECTIN Reactions: CA LO, BLD CHLORIDE LO, BLD CONGESTION, EYE(S)/LID CONSTIPATION CYANOSIS CYSTITIS DEAFNESS DEFECATION ABN DIARRHEA, MUCOID DIARRHEA, SEVERE DISSOCIATION DISTRESS, RESP FROTH, MOUTH/LIP(S) INEFFECT, TICKS INFECTION, SKIN IRRITATION, EYE(S)/LID K LO, BLD ODOR PR-APP SITE, LESION(S) PR-LUNG(S), LESION(S) PR-SKIN, LESION(S) PROPRIOCEPTIVE DISORDE PROTEIN(TOT) LO, BLD PROTEIN, URINE PUSTULE(S) RESPIRATORY DISORDER SHAKING, HEAD/FACE STAGGERING ANEMIA, AUTOIMMUNE HEM APPLICATION SITE HAIR, ABN COLOR APPLICATION SITE SKIN, DRY ARRHYTHMIA BLINDNESS BUN LO, BLD CHOLESTEROL HI, BLD DEATH(STILLBORN) DIABETES MELLITUS DISCHARGE, EAR(S) DISCOMFORT DISTRESS TOPICAL, CAT SELAMECTIN Reactions: DYSPHAGIA EOSINOS HI, BLD EYE DISORDER HAIR, ABN COLOR HEART DISORDER INFECTION, EYE(S) KIDNEY DISORDER LICKING, FEET/DIGIT(S) MIOSIS PAIN, BACK PARALYSIS, HIND LIMB(S PD-TUBE(S), ABN PRURITIS, TAIL REFLEX(ES) ABN RESIDUE, APPLICATION SITE SINUSITIS SKIN DISORDER SKIN, NECROSIS SWELLING, EYE(S)/LID(S THRASHING/PADDLING TREMBLING, FACE ULCER(S), MOUTH/LIP(S) ULCER(S), MUCOCUTANEOU US-LIVER ABN VESICLE(S)/BULLAE, SKI VOMITING, UNPRODUCTIVE WHEEZING ANEMIA, HEINZ BODY ANION GAP HI, BLD APPLICATION SITE EDEMA APPLICATION SITE MASS APPLICATION SITE, ALOPECIA ARREST, HEART ASCITES BILIRUBIN(DIR) HI, BLD BILIRUBIN(IND) HI, BLD BLD(ECCHYMOSES) BLD(HEMATOMA) BLD, SKIN BLOAT TOPICAL, CAT SELAMECTIN Reactions: CASTS, URINE CHLORIDE HI, BLD CNS DISORDER CONGESTION, LUNG(S) CONGESTION, NOSE CREATININE LO, BLD DEMENTIA DRY, SKIN DYSMETRIA DYSURIA EDEMA EDEMA, EYE(S)/LID(S) EFFUSION, PLEURAL ERUPTION(S) GGT HI, BLD HEPATOMEGALY INCONTINENCE, URINARY INEFFECT, NEMATODES IRRITATION IRRITATION, PHARYNX/TH KIDNEY VALUES HI, BLD LESION(S), RINGWORM LIVER DISORDER LYMPHS LO, BLD MICROORGANISMS, URINE NA HI, BLD NAUSEA NEPHRITIS NYSTAGMUS, HORIZONTAL ODOR, MOUTH PAPULE(S) PARALYSIS PARESIS, FORELIMB(S) PHARYNGITIS PNEUMONIA POLYCYTHEMIA PR-BONE MARROW, LESION PR-HEART, LESION(S) PR-SPLEEN, LESION(S) PROTRUSION, EYE(S) TOPICAL, CAT SELAMECTIN Reactions: RELUCTANT TO MOVE SEGS LO, BLD SPEC GRAVITY LO, URINE SPLENOMEGALY STARING STIFFNESS, HIND LIMB(S STUMBLING SWELLING, PHARYNX/THRO TENESMUS, URINARY THYROID HORMONE(S) LO URINATION VOMITING ROUNDWORMS WBC, URINE ABORTION ANEMIA, HEMOLYTIC ANURIA APNEA BALANCE DISORDER BANDS HI, BLD BEHAVOR DISORDER BILE ACIDS HI, BLD BIRTH DEFECT(S) BIRTH DEFECT(S), HEAD/ BIRTH DEFECT(S), LIMB( BIRTH DEFECT(S), TORSO BIRTH DEFFECT(S), FEET BIRTH, MULTIPLE BLD BLD, ABDOMEN BLD, MOUTH/LIP(S) BLINDNESS, PARTIAL CHOKING CO2 LO, BLD COAGULATION DISORDER COLITIS CONGESTION CONGESTION, PHARYNX CONGESTION, SINUS DEAFNESS, TEMP DEFECATION TOPICAL, CAT SELAMECTIN Reactions: DISCHARGE, MOUTH/LIP(S DISTENTION, ABDOMEN EAR DISORDER ECG ABN ECG, ABN EDEMA, VENTRAL ELIMINATION ABN ENLARGEMENT(S) ENLARGEMENT(S), SKIN FERTILITY, LACK OF FERTILITY, REDUCED FLATULENCE GLOBULIN LO, BLD GLUCOSE, URINE HCO3 LO, BLD HEAD BOBBING HEALING IMPAIRED HEART FAILURE HEPATITIS HYPERSENSITIVE, SOUND HYPERTONIA HYPOSMIA HYPOTHERMIA, EAR(S) INEFFECT INEFFECT, HOOKS PREVEN INEFFECT, MILK PROD INEFFECT, MITES INFECTION INFECTION, URINARY TRA INJ SITE ALOPECIA INJ SITE PRURITIS KETONES, URINE LIPASE HI, BLD LOCOMOTION DISORDER LOSS OF CONDITION LYMPHS HI, BLD MASS, SKIN MICROORANISMS, URINE MUCOUS MEMBR, ABN COLO NECROSIS TOPICAL, CAT SELAMECTIN Reactions: NEUROPATHY NO SIGNS NYSTAGMUS, POSITIONAL OBSTRUCTION, LARYNX OLIGURIA P LO, BLD PACING PANCREATITIS PARAESTHESIA, EYE(S)/L PARESTHESIA, MOUTH/LIP PD-CAP(S), ABN PD-TUBE(S), LEAKING PERITONITIS PHLEBITIS PHOTOPHOBIA PLATELETS HI, BLD POLYCYTHEMIA(ABSOLUTE) POLYCYTHEMIA(RELATIVE) PR-BLADDER, LESION(S) PR-COLON, LESION(S) PR-HEARTWORM DISEASE PR-INTEST, LESION(S) PR-KIDNEY(S), LESION(S PR-LUNG(S), EDEMA PR-MULT SITES, BLD PR-MULT SITES, CONGEST PR-MUSCLE(S), LESION(S) PR-NERVE(S), LESION(S) PR-PANCREAS, LESION(S) PR-SM INTEST, LESION(S PR-STILLBORN, LESION(S PR-STOMACH, LESION(S) PR-TONGUE, LESION(S) PRESSURE LO, BLD PROLAPSE, TONGUE PTT PROLONGED, BLD PUPIL(S), AREFLEXIA REGURGITATION, FOOD RETICULOCYTES LO, BLD ROLLING TOPICAL, CAT SELAMECTIN Reacted: SEBORRHEA SEDATION SEDIMENT, URINE SHOCK SKIN, DRY SLOUGH, SKIN SOUND ABN, RESPIRATORY SQUINTING STIFFNESS STIFFNESS, FRONT LIMB( STOMATITIS SWELLING, EAR(S) SWELLING, FEET/DIGIT(S SWELLING, MOUTH/LIP(S) SWELLING, NECK TENESMUS, RECTAL TORTICOLLIS TOX TRIGLYCERIDES HI, BLD ULCER(S), EAR(S) ULCER(S), FEET/DIGIT(S ULCER(S), TONGUE UREMIA US ABN VESTIBULAR DISORDER VOICE DISORDER WEIGHT INCREASE INEFFECT, HW LARVAE INEFFECT, FLEAS VOMITING DEPRESSION/LETHARGY DIARRHEA Lauren ________ See my cats: http://community.webshots.com/album/56955940rWhxAe Raw Diet Info: http://www.holisticat.com/drjletter.html http://www.geocities.com/rawfeeders/ForCatsOnly.html Declawing Info: http://www.wholecat.com/articles/claws.htm |
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