Ketoconazole and Revolution?

I have a kitten on Ketoconazole for ringworm. It's
time for his Revolution application. I can't find
any contraindications for using these two drugs at
the same time (one post found in google groups
suggested both to treat mange), but I'd like to know
if anyone has any concerns. The pill is given at the
rate of 1/8 of a 200 mg tablet twice daily.

More info on the kitten: He's 8 months old, neutered,
FeLV+ but otherwise healthy, active, good appetite
(I always give him the pill after feeding canned food),
playful, healthy coat. He is showing no problems
with the pill, and I will take him in to the vet next
week to get his blood checked.

The bald, crusty spot I found two weeks ago under
his right arm was about the size of my palm (average
hand size for a female). Now the spot is almost gone.
Treatment also includes Melaseb shampoo every 5
days and the topical cream (I forget the name).

BTW, his roommate, an 8 month old FeLV+
spayed female has shown no evidence of ringworm,
which I find curious (but nice!).

Thanks for any help. Gail

"Gail Futoran" wrote in message
...

I have a kitten on Ketoconazole for ringworm.

snip


More info on the kitten: He's 8 months old, neutered,
FeLV+

*Please* do not use Ketoconazole in your cat. Its an older (20 years) drug
and much more toxic to cats than the newer antifungal drugs. Ketoconazole's
rep is based on its efficacy in *dogs* (who handle it much better than cats)
*not* in cats.

Some vets still use Keto in cats because its so cheap compared to
Itraconazole (Sporonox) and Fluconazole (Difulcan) which are more effacious
and less toxic.

"Due to increased toxicity, ketoconazole should not be used in cats."

http://www.vin.com/VINDBPub/SearchPB...00/pr00110.htm


"Ketoconazole is usually not recommended for cats. Ketoconazole is capable
of numerous drug interactions due to inhibition of mammalian cytochrome
P-450."

http://www.dvmpharmaceuticals.com/dt111.html

"Also, the recent limited use of itraconazole in cats indicates that this
drug is better tolerated than ketoconazole, in that it appears to be less
hepatotoxic"

http://www.jaaha.org/cgi/content/full/39/6/543


Itraconazole (ITX) is the drug of choice for ringworm in cats and is a
breeze to administer. I found suspending ITZ in butter and giving the pats
as a treat was less stressful for the cat than pilling.

Most cats just love butter - and the fat increases absorption. I let one of
those little resturant-type butter tubs melt down at room temperature, then
thoroughly mix the 100 mg capsule in the liquified butter - then refrigerate
the tub. When the butter becomes solid, I cut the pat into four or five
equal pieces (depending on the cat) - each piece contains an equal amount of
drug - i.e., 5 pieces @ 20 mg.

A 4 kg (9 lb) cat usually gets 40 mg/day (or whatever my vet prescribes) -
so a 9 lb cat gets 2 pieces. I can cut those 2 pieces into smaller pieces
if necessary so that
the cat can gobble them right down. This method can't be used with all
meds, but it works like a charm with ITZ.

Lose the Keto.

Good luck.

Phil.

"How long does a cat stretch?
From one end of my life to the other"
--Me
Feline Healthcare - http://maxshouse.com
http://groups.yahoo.com/group/Feline..._and_Behavior/