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Enrofloxacin vs Orbafloxacin ?



 
 
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  #17  
Old November 20th 03, 03:46 PM
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Alison Perera wrote:
wrote:

Alison Perera wrote:
wrote:

I asked him if Orbifloxacin (recommended by Phil) is safer
but he said that there are not enough statistics to show
that it is safer. He said there are a lot more statistics
on Enrofloxacin because it's been used on millions of cats
during the past 10 years. So I told him that I wanted to
think about it for a few days.

Another fluoroquinolone is Zeniquin, which has been in use
on cats long enough (perhaps) to satisfy your vet. It is
pretty expensive though. I would also be wary of Baytril,
and I am disappointed with your vet's resistance to your
concerns.

-Alison in OH


My vet doesn't have Orbifloxacin in stock but I just called
an animal hospital in the area and found that they have it
(but the technician I talked to had never heard of Zeniquin).


Yngver is right, there's the issue of the organism's susceptibility to
the specific drug that could be influencing your vet's desire to use
that particular antibiotic. However, it only takes one dose of Baytril
to blind a cat. The vet I worked with used it on two animals while I was
there, both with bated breath--and both with excellent results against
infections that were resistant to everything else. Clearly, YMMV.

Zeniquin, or marbofloxacin, is produced by Pfizer. See
http://www.zeniquin.com/. I'm not making this stuff up.

-Alison in OH


As stated earlier the urine culture results came back negative.
My vet is assuming that she has a kidney infection but doesn't
know what kind of organism it is (if it's really an infection).

So it may not be easy to say if enrofloxacin or Orbifloxacin
will work better in this case.

Thanks again for the info.
  #18  
Old November 20th 03, 03:46 PM
external usenet poster
 
Posts: n/a
Default


Alison Perera wrote:
wrote:

Alison Perera wrote:
wrote:

I asked him if Orbifloxacin (recommended by Phil) is safer
but he said that there are not enough statistics to show
that it is safer. He said there are a lot more statistics
on Enrofloxacin because it's been used on millions of cats
during the past 10 years. So I told him that I wanted to
think about it for a few days.

Another fluoroquinolone is Zeniquin, which has been in use
on cats long enough (perhaps) to satisfy your vet. It is
pretty expensive though. I would also be wary of Baytril,
and I am disappointed with your vet's resistance to your
concerns.

-Alison in OH


My vet doesn't have Orbifloxacin in stock but I just called
an animal hospital in the area and found that they have it
(but the technician I talked to had never heard of Zeniquin).


Yngver is right, there's the issue of the organism's susceptibility to
the specific drug that could be influencing your vet's desire to use
that particular antibiotic. However, it only takes one dose of Baytril
to blind a cat. The vet I worked with used it on two animals while I was
there, both with bated breath--and both with excellent results against
infections that were resistant to everything else. Clearly, YMMV.

Zeniquin, or marbofloxacin, is produced by Pfizer. See
http://www.zeniquin.com/. I'm not making this stuff up.

-Alison in OH


As stated earlier the urine culture results came back negative.
My vet is assuming that she has a kidney infection but doesn't
know what kind of organism it is (if it's really an infection).

So it may not be easy to say if enrofloxacin or Orbifloxacin
will work better in this case.

Thanks again for the info.
  #19  
Old November 20th 03, 03:46 PM
external usenet poster
 
Posts: n/a
Default


Alison Perera wrote:
wrote:

Alison Perera wrote:
wrote:

I asked him if Orbifloxacin (recommended by Phil) is safer
but he said that there are not enough statistics to show
that it is safer. He said there are a lot more statistics
on Enrofloxacin because it's been used on millions of cats
during the past 10 years. So I told him that I wanted to
think about it for a few days.

Another fluoroquinolone is Zeniquin, which has been in use
on cats long enough (perhaps) to satisfy your vet. It is
pretty expensive though. I would also be wary of Baytril,
and I am disappointed with your vet's resistance to your
concerns.

-Alison in OH


My vet doesn't have Orbifloxacin in stock but I just called
an animal hospital in the area and found that they have it
(but the technician I talked to had never heard of Zeniquin).


Yngver is right, there's the issue of the organism's susceptibility to
the specific drug that could be influencing your vet's desire to use
that particular antibiotic. However, it only takes one dose of Baytril
to blind a cat. The vet I worked with used it on two animals while I was
there, both with bated breath--and both with excellent results against
infections that were resistant to everything else. Clearly, YMMV.

Zeniquin, or marbofloxacin, is produced by Pfizer. See
http://www.zeniquin.com/. I'm not making this stuff up.

-Alison in OH


As stated earlier the urine culture results came back negative.
My vet is assuming that she has a kidney infection but doesn't
know what kind of organism it is (if it's really an infection).

So it may not be easy to say if enrofloxacin or Orbifloxacin
will work better in this case.

Thanks again for the info.
  #20  
Old November 20th 03, 05:15 PM
Yngver
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Posts: n/a
Default

wrote:

As stated earlier the urine culture results came back negative.
My vet is assuming that she has a kidney infection but doesn't
know what kind of organism it is (if it's really an infection).

So it may not be easy to say if enrofloxacin or Orbifloxacin
will work better in this case.

Thanks again for the info.

I should add that in my case, my cat was clearly very sick and it wouldn't have
been prudent to waffle about whether to switch her from Baytril to Orbax when
she had not responded to other antibiotics prior to administering Baytil.

In your case, it's not even clear that your cat has an infection, correct? The
evidence was the blood in the urine sample, but is there any other sign of
infection? My cat was running a very high fever.

Here are some references you can look at:
http://www.vetmedcenter.com/professi...688&doctype=ED
http://www.tufts.edu/vet/vet_common/..._march2003.pdf

This second one from Tufts may have the info you are looking for. It describes
studies designed to determine a correlation between dosage of Baytril and Orbax
and retinal degeneration in cats. While both drugs produced incidences of
blindness at high dosages, the mfr of Orbax determined the drug to be safe at a
dosage of 15 mg/kg per day (although one cat did develop retinal degeneration
on this dosage), while Bayer's toxicity test of Baytril found no incidence of
retinal damage at the currently recommended max dosage of 5 mg/kg per day.

You may want to show this article to your vet, if you still want to argue the
case with him.
 




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