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canned food and hyperthyoidism?
The following appears in "Catnip," the newsletter from Cummings School of Veterinary Medicine at Tufts University, January 2006, Vol. 14 No. 1. It is part of an article titled "Spotlight on Vital Cat studies" by Karen Lee Stevens which includes an interview with Duncan C. Ferguson, VMD, PhD. It is in a question and answer format. Below is the introduction and an excerpt from the article: "Duncan C. Ferguson, VMD, PhD, a veterinarian who is board-certified in clinical pharmacology and internal medicine at the University of Georgia, has investigated hyperthyroidism in cats, since 1978. Q. As to a possible cause of hyperthyroidism in cats, can you briefly describe your theory? A. Other researchers have found a correlation between cats fed a canned food diet and incidences of hyperthyroidism. This may have something to do with the fact that cats do not metabolize certain kinds of compounds very well. Some of the compounds used to make the plastic liner in a cat food can have compounds called plasticizers. It is these types of structures that cats tend to be pretty slow at metabolizing. They may accumulate and influence thyroid glandular growth and function, most likely, by altering circulating concentrations of TSH." I hope Phil P, Steve Crane, and any veterinarians on the group will comment on this. Annie |
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canned food and hyperthyoidism?
Annie Wxill wrote: The following appears in "Catnip," the newsletter from Cummings School of Veterinary Medicine at Tufts University, January 2006, Vol. 14 No. 1. It is part of an article titled "Spotlight on Vital Cat studies" by Karen Lee Stevens which includes an interview with Duncan C. Ferguson, VMD, PhD. It is in a question and answer format. Below is the introduction and an excerpt from the article: "Duncan C. Ferguson, VMD, PhD, a veterinarian who is board-certified in clinical pharmacology and internal medicine at the University of Georgia, has investigated hyperthyroidism in cats, since 1978. Q. As to a possible cause of hyperthyroidism in cats, can you briefly describe your theory? A. Other researchers have found a correlation between cats fed a canned food diet and incidences of hyperthyroidism. This may have something to do with the fact that cats do not metabolize certain kinds of compounds very well. Some of the compounds used to make the plastic liner in a cat food can have compounds called plasticizers. It is these types of structures that cats tend to be pretty slow at metabolizing. They may accumulate and influence thyroid glandular growth and function, most likely, by altering circulating concentrations of TSH." I hope Phil P, Steve Crane, and any veterinarians on the group will comment on this. Annie Hi Annie, This controversy has pretty much died as a result of newer information and recognition of what an epidemiological study is all about. Epi studies are very important - but have severe limitations. They are important in giving us clues for future research. In an Epi study like this one, it is possible to look at thousands of animals and then record historical data about those animals habits. In this case Dr. Ferguson noted that hyperthyroidism was higher in cats being fed canned foods that had "pop-top" lids. Pop top lids work by having a very thin plastic like barrier under the top of the can lid. It was hypothesized that this plastic barrier might leach into the foods and cause hyperthyroidism. Subsequent testing of most major manufacturers foods did not find the chemical present in the food. An Epi study gives us a good place to start looking, but should NEVER be taken as establishing a causal relationship. One of my favorite examples of the fundamental failure of any Epi study is the following: My father ate green peas as a child, he died of colon cancer at age 34, therefore green peas cause colon cancer. While the first two parts of this statement are true - they do not make the third part of the statement true. Epi studies work much the same way. Looking for some causal relationship - in this case green peas. Cats fed from pop-top cans may have many other similarities in addition to being fed from pop-top cans. Are pop-top can fed cats more likley to be fed: 1. higher protein levels than cats fed commerical dry food. 2. fed by pet owners who have less time to spend with cats, and perhaps less excersize. 3. fed by owners who are more careful of thier cats and take them to the vet more often 4. fed by owners who are less careful of thier cats and don't take them to the vets. 5. more likely to be overweight due to being pampered by pet owners I don't know if many of these things are true, but they serve as examples of the dozens of other possibilities that cats fed pop-top cans might have in common as well and might impact the cats health. In December a year ago Dr. Karen Wedekind published her patent on hyperthyroid cats and within that patent was an understanding that higher protein levels may contribute to hyperthyroidism in cats due to increases of certain trace elements that are intrinsic to increased protein in cat foods. It isn't the increase in protein, but rather the increase in a couple trace minerals that come along with the protein materials. |
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canned food and hyperthyoidism?
"Annie Wxill" wrote in message ... The following appears in "Catnip," the newsletter from Cummings School of Veterinary Medicine at Tufts University, January 2006, Vol. 14 No. 1. It is part of an article titled "Spotlight on Vital Cat studies" by Karen Lee Stevens which includes an interview with Duncan C. Ferguson, VMD, PhD. It is in a question and answer format. Below is the introduction and an excerpt from the article: "Duncan C. Ferguson, VMD, PhD, a veterinarian who is board-certified in clinical pharmacology and internal medicine at the University of Georgia, has investigated hyperthyroidism in cats, since 1978. Q. As to a possible cause of hyperthyroidism in cats, can you briefly describe your theory? A. Other researchers have found a correlation between cats fed a canned food diet and incidences of hyperthyroidism. This may have something to do with the fact that cats do not metabolize certain kinds of compounds very well. Some of the compounds used to make the plastic liner in a cat food can have compounds called plasticizers. It is these types of structures that cats tend to be pretty slow at metabolizing. They may accumulate and influence thyroid glandular growth and function, most likely, by altering circulating concentrations of TSH." I hope Phil P, Steve Crane, and any veterinarians on the group will comment on this. Annie, A few of these studies have been published in the past few years- one said cats that ate canned fish or liver and giblets had an increased risk of hyperthyroidism- another said pop-top cans increased the risk, and another just said eating canned food increased the risk. These are all epidemiologic studies rather than clinical medical studies. Also, the results were based on owner observation rather than on hard medical data. None of these dubious claims have ever been supported by actual chemical tests on cat blood or T4 that could explain how canned food or the coating on the inside of the cans can cause hyperthyroidism. None of the chemicals in the coating were ever found in the food and no differences were ever found in cat food that was packaged in cans or glass. I've been feeding canned food for more than 40 years and only one of my cats ever developed hyperthyroidism. I don't think people should stop feeding canned food because of the results of these types of studies. I sure won't. Phil |
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canned food and hyperthyoidism?
"Steve Crane" wrote in message oups.com... .... Hi Annie, This controversy has pretty much died as a result of newer information ... In December a year ago Dr. Karen Wedekind published her patent on hyperthyroid cats and within that patent was an understanding that higher protein levels may contribute to hyperthyroidism in cats due to increases of certain trace elements that are intrinsic to increased protein in cat foods. It isn't the increase in protein, but rather the increase in a couple trace minerals that come along with the protein materials. Steve, Thanks for your detailed reply. I understand how wrong conclusions can result from the juxtaposition of two (or more) true observations. I would expect to see better reporting and/or editing in a newsletter that comes from a vet school at a well-known and respected university. Although they are not in the same category as what appears in scientific journals, I would hope that the information such newsletters provide to the general public would be current and accurate. What are the trace minerals that come along with the protein and what amounts of those minerals would be optimal? Thanks again, Annie |
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canned food and hyperthyoidism?
"Phil P." wrote in message k.net... Annie, .... None of these dubious claims have ever been supported by actual chemical tests on cat blood or T4 that could explain how canned food or the coating on the inside of the cans can cause hyperthyroidism. None of the chemicals in the coating were ever found in the food and no differences were ever found in cat food that was packaged in cans or glass. .... Phil Thanks Phil, As I said in my reply to Steve Crane, I think that although it is not a scientific journal, I would expect that a newsletter from a well-known vet school owes its readers information that is as current as possible and not misleading. I wonder if anyone will call them on it. I'm sorry to have to snip the majority of your reply. My news server, or reader, or whatever it is, will reject messages if my reply is a lot shorter than your message. Annie |
#6
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canned food and hyperthyoidism?
Annie Wxill wrote: "Steve Crane" wrote in message oups.com... ... Hi Annie, This controversy has pretty much died as a result of newer information ... In December a year ago Dr. Karen Wedekind published her patent on hyperthyroid cats and within that patent was an understanding that higher protein levels may contribute to hyperthyroidism in cats due to increases of certain trace elements that are intrinsic to increased protein in cat foods. It isn't the increase in protein, but rather the increase in a couple trace minerals that come along with the protein materials. Steve, Thanks for your detailed reply. I understand how wrong conclusions can result from the juxtaposition of two (or more) true observations. I would expect to see better reporting and/or editing in a newsletter that comes from a vet school at a well-known and respected university. Although they are not in the same category as what appears in scientific journals, I would hope that the information such newsletters provide to the general public would be current and accurate. My guess would be that it was designed for veterinarians who would recognize an Epi study for what is was. Perhaps they didn't / don't realize that there is a wider audience reading the newsletter. What are the trace minerals that come along with the protein and what amounts of those minerals would be optimal? selenium at 0.65 mgs/kg and iodine - I don't have the patent on this machine and can't remember the values, but it probably wouldn't do much god anyway as I doubt many manufacturers can or would provide the levels in the foods they produce. At this point I wouldn't get too worried about it. Thanks again, Annie |
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canned food and hyperthyoidism?
"Steve Crane" wrote in message ups.com... My guess would be that it was designed for veterinarians who would recognize an Epi study for what is was. Perhaps they didn't / don't realize that there is a wider audience reading the newsletter. .... The publication says on the header that it is "The Newsletter for Caring Cat Owners." It is a monthly publication that covers a number of subjects of interest. For example, the issue in question also has articles on adopting special needs cats, introducing dogs and cats, new products (litter box scoops, toys, etc.), and IBD. I suspect that Dr. Ferguson's comments, if any, about how the research was conducted and correlation was made, were omitted by the writer or cut for space by the editor. The next question asks "What is the goal of your study?" Dr. Ferguson answers, "Our goal is to obtain a valid, documented glycopeptide standard for feline TSH and to characterize its behavior with some immunological reagents we had already developed against dog TSH. A sensitive non-invasive test is needed to aid in earlier and more accurate diagnosis of hyperthyroidism. By including the accurate measurement of TSH in the diagnostic procedures for hyperthyroidism, we should be able to detect the disease in its early stages." Annie |
#8
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canned food and hyperthyoidism?
"Annie Wxill" wrote in message ... "Steve Crane" wrote in message ups.com... My guess would be that it was designed for veterinarians who would recognize an Epi study for what is was. Perhaps they didn't / don't realize that there is a wider audience reading the newsletter. ... The publication says on the header that it is "The Newsletter for Caring Cat Owners." It is a monthly publication that covers a number of subjects of interest. For example, the issue in question also has articles on adopting special needs cats, introducing dogs and cats, new products (litter box scoops, toys, etc.), and IBD. I suspect that Dr. Ferguson's comments, if any, about how the research was conducted and correlation was made, were omitted by the writer or cut for space by the editor. The article in Catnip was based on studies that were actually published in the Journal of the American Veterinary Assoc. So, technically, they can "back up" the article with "scientific documentation". I think publishing an article like that for pet owners was very poor judgment. Catnip should have stated that the article was based on mail-order, owner-opinion epidemiological studies rather than controlled, clinical medical studies and that no causal association between canned food and hyperthyroidism has *ever* been found. Because Tufts is a credible institution, many people will accept the article as gospel and I'm afraid they will needlessly switch their cat's food to dry. There's also a study in the Journal of Veterinary Internal Medicine that implies 2-3-fold increase in risk of hyperthyroidism in cats fed canned food and a 3-fold increase in risk of hyperthyroidism in cats that use litter. With more than 60 million cats using litter- hyperthyroidism should be reported in epidemic proportions! I'm sure a study could find an increased risk of some diseases in cats that are petted between 9 am and 10 am than cats petted between 2-3 pm- if you get my drift. The next question asks "What is the goal of your study?" Dr. Ferguson answers, "Our goal is to obtain a valid, documented glycopeptide standard for feline TSH and to characterize its behavior with some immunological reagents we had already developed against dog TSH. A sensitive non-invasive test is needed to aid in earlier and more accurate diagnosis of hyperthyroidism. By including the accurate measurement of TSH in the diagnostic procedures for hyperthyroidism, we should be able to detect the disease in its early stages." A test for early detection of hyperthyroidism and for when T4 is falsely depressed due to other illneness already exists- its called Free T4 by Equilibrium Dialysis and costs about $20. The blood sample is dialyzed before its assayed. Sounds like Fergy is trying insure his job security by trying to drum up funding for a study. Merry Christmas Phil |
#9
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canned food and hyperthyoidism?
"Phil P." wrote in message ink.net... ...I think publishing an article like that for pet owners was very poor judgment. Catnip should have stated that the article was based on mail-order, owner-opinion epidemiological studies rather than controlled, clinical medical studies and that no causal association between canned food and hyperthyroidism has *ever* been found. ... Because Tufts is a credible institution, many people will accept the article as gospel and I'm afraid they will needlessly switch their cat's food to dry. ... A test for early detection of hyperthyroidism and for when T4 is falsely depressed due to other illneness already exists- its called Free T4 by Equilibrium Dialysis and costs about $20. The blood sample is dialyzed before its assayed. ... Phil Merry Christmas back to you, Phil. In addition to hyperthyroidism, the article included information about research of diabetes, cancer of the oral cavity, the effects of lysine on upper-respiratory disease and urinary diseases. I agree that poor judgment was made in publishing, at least the portion we have discussed here, and not mentioning the type of study. It certainly got my attention because I want to feed our cats what is best for them (although, they don't always agree) with an emphasis on canned food. But, they do want their "crunchies" and I'll give them a few before bedtime. I know they would prefer that we switch from canned to dry, but I've learned too much from this group about the risks involved, which is why I questioned the information presented in the article. I suspect that the article tried to cram too many topics into too little space and left out some important points. You'd expect more care and better editing from a well-known and respected institution because not everyone will question what is presented. However, I do believe that the topic of the article, which was an overview of some research on certain diseases, was good. I expect that more detailed information on each of these topics will be published in later issues. Overall, I think the publication is good and I have subscribed for many years. Annie |
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